pubmed-article:1684247 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:1684247 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:1684247 | lifeskim:mentions | umls-concept:C0229664 | lld:lifeskim |
pubmed-article:1684247 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
pubmed-article:1684247 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
pubmed-article:1684247 | lifeskim:mentions | umls-concept:C0443286 | lld:lifeskim |
pubmed-article:1684247 | lifeskim:mentions | umls-concept:C0439859 | lld:lifeskim |
pubmed-article:1684247 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
pubmed-article:1684247 | lifeskim:mentions | umls-concept:C0205132 | lld:lifeskim |
pubmed-article:1684247 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
pubmed-article:1684247 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
pubmed-article:1684247 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
pubmed-article:1684247 | pubmed:issue | 6 | lld:pubmed |
pubmed-article:1684247 | pubmed:dateCreated | 1992-1-22 | lld:pubmed |
pubmed-article:1684247 | pubmed:abstractText | T lymphocyte interactions have generally been described between discrete functional subsets. In our investigation of murine T-cell interactions we described a type of T-T interaction termed the 'Syngeneic T-T Lymphocyte Reaction' in which activated T-cell clones stimulated the proliferation of resting T cells mainly through a mechanism involving cell to cell contact. To investigate whether similar reactions occur in the human immune system we used the human autoreactive T-cell line C.1 to stimulate peripheral T cells. Line C.1 cells, which are not transformed and do not secrete IL2, consistently caused proliferation of purified freshly isolated autologous peripheral human T cells as measured by a [3H]-thymidine incorporation assay. The proliferation was seen in both the CD4 and CD8 subsets and could be inhibited with anti-DR and anti-CD2 antibodies. The stimulation is not due to carryover of classical antigen-presenting cells or to the C.1 line cells acting as antigen-presenting cells. We propose that some activated T cells, probably by expression of a surface molecule, can stimulate resting T cells thereby allowing for antigen-non-specific augmentation of the immune response. | lld:pubmed |
pubmed-article:1684247 | pubmed:language | eng | lld:pubmed |
pubmed-article:1684247 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1684247 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:1684247 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1684247 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1684247 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1684247 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1684247 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1684247 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1684247 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:1684247 | pubmed:month | Dec | lld:pubmed |
pubmed-article:1684247 | pubmed:issn | 0300-9475 | lld:pubmed |
pubmed-article:1684247 | pubmed:author | pubmed-author:ParksLL | lld:pubmed |
pubmed-article:1684247 | pubmed:author | pubmed-author:QuintansJJ | lld:pubmed |
pubmed-article:1684247 | pubmed:author | pubmed-author:SwartzT JTJ | lld:pubmed |
pubmed-article:1684247 | pubmed:author | pubmed-author:EvavoldBB | lld:pubmed |
pubmed-article:1684247 | pubmed:author | pubmed-author:Ditzian-Kadan... | lld:pubmed |
pubmed-article:1684247 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:1684247 | pubmed:volume | 34 | lld:pubmed |
pubmed-article:1684247 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:1684247 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:1684247 | pubmed:pagination | 713-9 | lld:pubmed |
pubmed-article:1684247 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
pubmed-article:1684247 | pubmed:meshHeading | pubmed-meshheading:1684247-... | lld:pubmed |
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pubmed-article:1684247 | pubmed:year | 1991 | lld:pubmed |
pubmed-article:1684247 | pubmed:articleTitle | Stimulation of peripheral blood T cells by an activated T-cell line: a novel human autologous T-T lymphocyte reaction. | lld:pubmed |
pubmed-article:1684247 | pubmed:affiliation | Department of Medicine, University of Chicago, Illinois. | lld:pubmed |
pubmed-article:1684247 | pubmed:publicationType | Journal Article | lld:pubmed |