| pubmed-article:1684103 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1684103 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:1684103 | lifeskim:mentions | umls-concept:C0007804 | lld:lifeskim |
| pubmed-article:1684103 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:1684103 | lifeskim:mentions | umls-concept:C1517499 | lld:lifeskim |
| pubmed-article:1684103 | pubmed:dateCreated | 1992-1-15 | lld:pubmed |
| pubmed-article:1684103 | pubmed:abstractText | Metachromatic leukodystrophy is a lysosomal storage disease caused by the deficiency of arylsulphatase A (ASA). A human ASA cDNA was subcloned into the retroviral vector pXT1. Replication-defective retrovirus was generated by transfection of the vector into the amphotropic packaging cell line PA317. Human fibroblasts from a patient suffering from metachromatic leucodystrophy was infected with the recombinant retrovirus. Infected fibroblasts expressed ten times more ASA compared with control fibroblasts from a normal individual. The ASA encoded by the integrated provirus was shown to be correctly transported into the lysosomes and to normalize the impaired degradation of cerebroside sulphate. | lld:pubmed |
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| pubmed-article:1684103 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1684103 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1684103 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1684103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1684103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1684103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1684103 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1684103 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1684103 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:1684103 | pubmed:author | pubmed-author:FluhartyA LAL | lld:pubmed |
| pubmed-article:1684103 | pubmed:author | pubmed-author:von FiguraKK | lld:pubmed |
| pubmed-article:1684103 | pubmed:author | pubmed-author:PetersCC | lld:pubmed |
| pubmed-article:1684103 | pubmed:author | pubmed-author:GieselmannVV | lld:pubmed |
| pubmed-article:1684103 | pubmed:author | pubmed-author:RommerskirchW... | lld:pubmed |
| pubmed-article:1684103 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1684103 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1684103 | pubmed:volume | 280 ( Pt 2) | lld:pubmed |
| pubmed-article:1684103 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1684103 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1684103 | pubmed:pagination | 459-61 | lld:pubmed |
| pubmed-article:1684103 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:1684103 | pubmed:meshHeading | pubmed-meshheading:1684103-... | lld:pubmed |
| pubmed-article:1684103 | pubmed:meshHeading | pubmed-meshheading:1684103-... | lld:pubmed |
| pubmed-article:1684103 | pubmed:meshHeading | pubmed-meshheading:1684103-... | lld:pubmed |
| pubmed-article:1684103 | pubmed:meshHeading | pubmed-meshheading:1684103-... | lld:pubmed |
| pubmed-article:1684103 | pubmed:meshHeading | pubmed-meshheading:1684103-... | lld:pubmed |
| pubmed-article:1684103 | pubmed:meshHeading | pubmed-meshheading:1684103-... | lld:pubmed |
| pubmed-article:1684103 | pubmed:meshHeading | pubmed-meshheading:1684103-... | lld:pubmed |
| pubmed-article:1684103 | pubmed:meshHeading | pubmed-meshheading:1684103-... | lld:pubmed |
| pubmed-article:1684103 | pubmed:meshHeading | pubmed-meshheading:1684103-... | lld:pubmed |
| pubmed-article:1684103 | pubmed:meshHeading | pubmed-meshheading:1684103-... | lld:pubmed |
| pubmed-article:1684103 | pubmed:meshHeading | pubmed-meshheading:1684103-... | lld:pubmed |
| pubmed-article:1684103 | pubmed:meshHeading | pubmed-meshheading:1684103-... | lld:pubmed |
| pubmed-article:1684103 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1684103 | pubmed:articleTitle | Restoration of arylsulphatase A activity in human-metachromatic-leucodystrophy fibroblasts via retroviral-vector-mediated gene transfer. | lld:pubmed |
| pubmed-article:1684103 | pubmed:affiliation | Universität Göttingen, Abteilung Biochemie II, Federal Republic of Germany. | lld:pubmed |
| pubmed-article:1684103 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1684103 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1684103 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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