| pubmed-article:1684084 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1684084 | lifeskim:mentions | umls-concept:C0012634 | lld:lifeskim |
| pubmed-article:1684084 | lifeskim:mentions | umls-concept:C0025267 | lld:lifeskim |
| pubmed-article:1684084 | lifeskim:mentions | umls-concept:C1140618 | lld:lifeskim |
| pubmed-article:1684084 | lifeskim:mentions | umls-concept:C0205107 | lld:lifeskim |
| pubmed-article:1684084 | lifeskim:mentions | umls-concept:C0008643 | lld:lifeskim |
| pubmed-article:1684084 | lifeskim:mentions | umls-concept:C0008653 | lld:lifeskim |
| pubmed-article:1684084 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:1684084 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:1684084 | lifeskim:mentions | umls-concept:C1253949 | lld:lifeskim |
| pubmed-article:1684084 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1684084 | pubmed:dateCreated | 1992-1-10 | lld:pubmed |
| pubmed-article:1684084 | pubmed:abstractText | We describe a high-resolution radiation hybrid map of the proximal long arm of human chromosome 11 containing the bcl-1 and multiple endocrine neoplasia type 1 (MEN-1) disease gene loci. We used X-ray irradiation and cell fusion to generate a panel of 102 hamster-human somatic cell hybrids containing fragments of human chromosome 11. Sixteen human loci in the 11q12-13 region were mapped by statistical analysis of the cosegregation of markers in these radiation hybrids. The most likely order for these loci is C1NH-OSBP-(CD5/CD20)-PGA-FTH1-COX8-PYGM -SEA-KRN1-(MTC/P11EH/HSTF1/INT2)-GST3- PPP1A. Our localization of the human protooncogene SEA between PYGM and INT2, two markers that flank MEN-1, suggests SEA as a potential candidate for the MEN-1 locus. We map two mitogenic fibroblast growth factor genes, HSTF1 and INT2, close to bcl-1, a mapping that is consistent with previously published data. Our map places the human leukocyte antigen genes CD5 and CD20 far from the bcl-1 locus, indicating that CD5 and CD20 expression is unlikely to be altered by bcl-1 rearrangements. PPP1A, which has been postulated as a MEN-1 candidate tumor suppressor gene, and GST3, a gene transcriptionally active in many human cancers, both map distal to the bcl-1 translocation cluster and the region containing MEN-1, and therefore are unlikely to be directly involved in bcl-1 or MEN-1. | lld:pubmed |
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| pubmed-article:1684084 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1684084 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1684084 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1684084 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1684084 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1684084 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1684084 | pubmed:issn | 0002-9297 | lld:pubmed |
| pubmed-article:1684084 | pubmed:author | pubmed-author:CoxD RDR | lld:pubmed |
| pubmed-article:1684084 | pubmed:author | pubmed-author:EvansG AGA | lld:pubmed |
| pubmed-article:1684084 | pubmed:author | pubmed-author:RichardC... | lld:pubmed |
| pubmed-article:1684084 | pubmed:author | pubmed-author:MeekerT CTC | lld:pubmed |
| pubmed-article:1684084 | pubmed:author | pubmed-author:MaurerSS | lld:pubmed |
| pubmed-article:1684084 | pubmed:author | pubmed-author:MyersR MRM | lld:pubmed |
| pubmed-article:1684084 | pubmed:author | pubmed-author:WithersD ADA | lld:pubmed |
| pubmed-article:1684084 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1684084 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:1684084 | pubmed:geneSymbol | PGA | lld:pubmed |
| pubmed-article:1684084 | pubmed:geneSymbol | CD20 | lld:pubmed |
| pubmed-article:1684084 | pubmed:geneSymbol | PPP1A | lld:pubmed |
| pubmed-article:1684084 | pubmed:geneSymbol | PYGM | lld:pubmed |
| pubmed-article:1684084 | pubmed:geneSymbol | GST3 | lld:pubmed |
| pubmed-article:1684084 | pubmed:geneSymbol | HSTF1 | lld:pubmed |
| pubmed-article:1684084 | pubmed:geneSymbol | CD5 | lld:pubmed |
| pubmed-article:1684084 | pubmed:geneSymbol | FTH1 | lld:pubmed |
| pubmed-article:1684084 | pubmed:geneSymbol | C1NH | lld:pubmed |
| pubmed-article:1684084 | pubmed:geneSymbol | INT2 | lld:pubmed |
| pubmed-article:1684084 | pubmed:geneSymbol | OSBP | lld:pubmed |
| pubmed-article:1684084 | pubmed:geneSymbol | COX8 | lld:pubmed |
| pubmed-article:1684084 | pubmed:geneSymbol | KRN1 | lld:pubmed |
| pubmed-article:1684084 | pubmed:geneSymbol | bcl-1 MTC | lld:pubmed |
| pubmed-article:1684084 | pubmed:geneSymbol | bcl-1 P11EH | lld:pubmed |
| pubmed-article:1684084 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1684084 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1684084 | pubmed:pagination | 1189-96 | lld:pubmed |
| pubmed-article:1684084 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1684084 | pubmed:meshHeading | pubmed-meshheading:1684084-... | lld:pubmed |
| pubmed-article:1684084 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1684084 | pubmed:articleTitle | A radiation hybrid map of the proximal long arm of human chromosome 11 containing the multiple endocrine neoplasia type 1 (MEN-1) and bcl-1 disease loci. | lld:pubmed |
| pubmed-article:1684084 | pubmed:affiliation | Department of Psychiatry, University of California, San Francisco 94143-0554. | lld:pubmed |
| pubmed-article:1684084 | pubmed:publicationType | Journal Article | lld:pubmed |
