| pubmed-article:16840778 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16840778 | lifeskim:mentions | umls-concept:C0024554 | lld:lifeskim |
| pubmed-article:16840778 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:16840778 | lifeskim:mentions | umls-concept:C0160390 | lld:lifeskim |
| pubmed-article:16840778 | lifeskim:mentions | umls-concept:C0017037 | lld:lifeskim |
| pubmed-article:16840778 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:16840778 | pubmed:issue | 39 | lld:pubmed |
| pubmed-article:16840778 | pubmed:dateCreated | 2006-9-25 | lld:pubmed |
| pubmed-article:16840778 | pubmed:abstractText | Acetaminophen overdose is a leading cause of drug-related acute liver failure in the United States. Glutathione, a tripeptide antioxidant protects cells against oxidative damage from reactive oxygen species and plays a crucial role in the detoxification of xenobiotics, including acetaminophen. Glutathione is synthesized in a two-step enzymatic reaction. Glutamate-cysteine ligase carries out the rate-limiting and first step in glutathione synthesis. We have generated C57Bl/6 mice that conditionally overexpress glutamate-cysteine ligase, and report here their resistance to acetaminophen-induced liver injury. Indices of liver injury included histopathology and serum alanine aminotransferase activity. Male transgenic mice induced to overexpress glutamate-cysteine ligase exhibited resistance to acetaminophen-induced liver injury when compared with acetaminophen-treated male mice carrying, but not expressing glutamate-cysteine ligase transgenes, or to female glutamate-cysteine ligase transgenic mice. We conclude that glutamate-cysteine ligase activity is an important factor in determining acetaminophen-induced liver injury in C57Bl/6 male mice. Because people are known to vary in their glutamate-cysteine ligase activity, this enzyme may also be an important determinant of sensitivity to acetaminophen-induced liver injury in humans. | lld:pubmed |
| pubmed-article:16840778 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16840778 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16840778 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16840778 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16840778 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16840778 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16840778 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16840778 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16840778 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16840778 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16840778 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16840778 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:16840778 | pubmed:author | pubmed-author:FaustoNelsonN | lld:pubmed |
| pubmed-article:16840778 | pubmed:author | pubmed-author:Srinouanprach... | lld:pubmed |
| pubmed-article:16840778 | pubmed:author | pubmed-author:KavanaghTerra... | lld:pubmed |
| pubmed-article:16840778 | pubmed:author | pubmed-author:PierceRobert... | lld:pubmed |
| pubmed-article:16840778 | pubmed:author | pubmed-author:WhiteCollin... | lld:pubmed |
| pubmed-article:16840778 | pubmed:author | pubmed-author:FarinFederico... | lld:pubmed |
| pubmed-article:16840778 | pubmed:author | pubmed-author:WareCarol BCB | lld:pubmed |
| pubmed-article:16840778 | pubmed:author | pubmed-author:DabrowskiMich... | lld:pubmed |
| pubmed-article:16840778 | pubmed:author | pubmed-author:LadigesWarren... | lld:pubmed |
| pubmed-article:16840778 | pubmed:author | pubmed-author:BottaDianneD | lld:pubmed |
| pubmed-article:16840778 | pubmed:author | pubmed-author:ShiShengliS | lld:pubmed |
| pubmed-article:16840778 | pubmed:author | pubmed-author:KeenerCassie... | lld:pubmed |
| pubmed-article:16840778 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16840778 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:16840778 | pubmed:volume | 281 | lld:pubmed |
| pubmed-article:16840778 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16840778 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16840778 | pubmed:pagination | 28865-75 | lld:pubmed |
| pubmed-article:16840778 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
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| pubmed-article:16840778 | pubmed:meshHeading | pubmed-meshheading:16840778... | lld:pubmed |
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| pubmed-article:16840778 | pubmed:meshHeading | pubmed-meshheading:16840778... | lld:pubmed |
| pubmed-article:16840778 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16840778 | pubmed:articleTitle | Acetaminophen-induced liver injury is attenuated in male glutamate-cysteine ligase transgenic mice. | lld:pubmed |
| pubmed-article:16840778 | pubmed:affiliation | Department of Environmental and Occupational Health Sciences, Comparative Medicine, and Pathology, and UW/NIEHS Center for Ecogenetics and Environmental Health, University of Washington, Seattle, Washington 68105, USA. | lld:pubmed |
| pubmed-article:16840778 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16840778 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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