| pubmed-article:16829163 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16829163 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:16829163 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:16829163 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:16829163 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16829163 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:16829163 | lifeskim:mentions | umls-concept:C0026006 | lld:lifeskim |
| pubmed-article:16829163 | lifeskim:mentions | umls-concept:C0025810 | lld:lifeskim |
| pubmed-article:16829163 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16829163 | pubmed:dateCreated | 2006-7-31 | lld:pubmed |
| pubmed-article:16829163 | pubmed:abstractText | Methylphenidate (MPH) is one of the most frequently prescribed drugs for the treatment of attention deficit hyperactivity disorder (ADHD). A report on cytogenetic effects observed in peripheral lymphocytes from children treated for 3 months with MPH raised questions about the genetic toxicity of this compound. A critical review of this data concluded that the cytogenetic effects in treated children remain unexplained. A literature review showed that MPH was found negative in most genetox studies performed, but no in vitro chromosome aberration data in human lymphocytes have been published. Therefore, we conducted a chromosomal aberration study in cultured human peripheral lymphocytes. The results of this investigation showed that d,l-methylphenidate (MPH, Ritalin) in concentrations up to 10 mM did neither induce structural nor numerical chromosome abnormalities. An oral mouse bone-marrow micronucleus test in B6C3F(1) mice, with doses up to 250 mg/kg bw, was negative too. The data of these studies confirm the absence of clastogenic activity of MPH in non-clinical studies. | lld:pubmed |
| pubmed-article:16829163 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16829163 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16829163 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16829163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16829163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16829163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16829163 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16829163 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16829163 | pubmed:issn | 0027-5107 | lld:pubmed |
| pubmed-article:16829163 | pubmed:author | pubmed-author:SuterWilliW | lld:pubmed |
| pubmed-article:16829163 | pubmed:author | pubmed-author:MartusHans-Jo... | lld:pubmed |
| pubmed-article:16829163 | pubmed:author | pubmed-author:ElhajoujiAzed... | lld:pubmed |
| pubmed-article:16829163 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16829163 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:16829163 | pubmed:volume | 607 | lld:pubmed |
| pubmed-article:16829163 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16829163 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16829163 | pubmed:pagination | 153-9 | lld:pubmed |
| pubmed-article:16829163 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16829163 | pubmed:meshHeading | pubmed-meshheading:16829163... | lld:pubmed |
| pubmed-article:16829163 | pubmed:meshHeading | pubmed-meshheading:16829163... | lld:pubmed |
| pubmed-article:16829163 | pubmed:meshHeading | pubmed-meshheading:16829163... | lld:pubmed |
| pubmed-article:16829163 | pubmed:meshHeading | pubmed-meshheading:16829163... | lld:pubmed |
| pubmed-article:16829163 | pubmed:meshHeading | pubmed-meshheading:16829163... | lld:pubmed |
| pubmed-article:16829163 | pubmed:meshHeading | pubmed-meshheading:16829163... | lld:pubmed |
| pubmed-article:16829163 | pubmed:meshHeading | pubmed-meshheading:16829163... | lld:pubmed |
| pubmed-article:16829163 | pubmed:meshHeading | pubmed-meshheading:16829163... | lld:pubmed |
| pubmed-article:16829163 | pubmed:meshHeading | pubmed-meshheading:16829163... | lld:pubmed |
| pubmed-article:16829163 | pubmed:meshHeading | pubmed-meshheading:16829163... | lld:pubmed |
| pubmed-article:16829163 | pubmed:meshHeading | pubmed-meshheading:16829163... | lld:pubmed |
| pubmed-article:16829163 | pubmed:meshHeading | pubmed-meshheading:16829163... | lld:pubmed |
| pubmed-article:16829163 | pubmed:meshHeading | pubmed-meshheading:16829163... | lld:pubmed |
| pubmed-article:16829163 | pubmed:meshHeading | pubmed-meshheading:16829163... | lld:pubmed |
| pubmed-article:16829163 | pubmed:meshHeading | pubmed-meshheading:16829163... | lld:pubmed |
| pubmed-article:16829163 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16829163 | pubmed:articleTitle | Methylphenidate is not clastogenic in cultured human lymphocytes and in the mouse bone-marrow micronucleus test. | lld:pubmed |
| pubmed-article:16829163 | pubmed:affiliation | Safety Assessment and Profiling, Exploratory Development, Novartis Pharma AG, MUT-2881.2.35, CH4002 Basel, Switzerland. willi.suter@novartis.com | lld:pubmed |
| pubmed-article:16829163 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16829163 | pubmed:publicationType | Comparative Study | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16829163 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16829163 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16829163 | lld:pubmed |
