| pubmed-article:16827112 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16827112 | lifeskim:mentions | umls-concept:C0011957 | lld:lifeskim |
| pubmed-article:16827112 | lifeskim:mentions | umls-concept:C0032207 | lld:lifeskim |
| pubmed-article:16827112 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:16827112 | lifeskim:mentions | umls-concept:C1704241 | lld:lifeskim |
| pubmed-article:16827112 | lifeskim:mentions | umls-concept:C1548818 | lld:lifeskim |
| pubmed-article:16827112 | lifeskim:mentions | umls-concept:C0678717 | lld:lifeskim |
| pubmed-article:16827112 | pubmed:issue | 3A | lld:pubmed |
| pubmed-article:16827112 | pubmed:dateCreated | 2006-7-7 | lld:pubmed |
| pubmed-article:16827112 | pubmed:abstractText | Platinum (II) complexes are accredited with biological activities. New complexes with thiepane dioxide diamine as ligands, characterized by defined stereochemical features, a flexible 7-membered thiepane moiety and by C2 symmetry, were prepared. The complexes, related to the diamino cyclohexane family of platinum complexes, were soluble in dimethyl sulfoxide with the solvent substituting one chloride ion. These positively-charged complexes were tested against a human carcinoma cell line A431 and its cisplatin-resistant counterpart A431/Pt and were found to show: i) capability in bypassing cisplatin-resistance; ii) cytotoxicity comparable to that of oxaliplatin; iii) lower activity than cisplatin. In both cells lines, [PtCl(DACH)(DMSO)]+ was more cytotoxic than oxaliplatin. The best activity was shown by the platinum complexes with ligands which presented C2 symmetry. | lld:pubmed |
| pubmed-article:16827112 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16827112 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16827112 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16827112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16827112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16827112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16827112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16827112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16827112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16827112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16827112 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16827112 | pubmed:issn | 0250-7005 | lld:pubmed |
| pubmed-article:16827112 | pubmed:author | pubmed-author:GrossiLorisL | lld:pubmed |
| pubmed-article:16827112 | pubmed:author | pubmed-author:MartelliMario... | lld:pubmed |
| pubmed-article:16827112 | pubmed:author | pubmed-author:MartelliLaura... | lld:pubmed |
| pubmed-article:16827112 | pubmed:author | pubmed-author:MunariDaniela... | lld:pubmed |
| pubmed-article:16827112 | pubmed:author | pubmed-author:CerèVandaV | lld:pubmed |
| pubmed-article:16827112 | pubmed:author | pubmed-author:PollicinoSalv... | lld:pubmed |
| pubmed-article:16827112 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16827112 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:16827112 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16827112 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16827112 | pubmed:pagination | 1815-9 | lld:pubmed |
| pubmed-article:16827112 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16827112 | pubmed:meshHeading | pubmed-meshheading:16827112... | lld:pubmed |
| pubmed-article:16827112 | pubmed:meshHeading | pubmed-meshheading:16827112... | lld:pubmed |
| pubmed-article:16827112 | pubmed:meshHeading | pubmed-meshheading:16827112... | lld:pubmed |
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| pubmed-article:16827112 | pubmed:meshHeading | pubmed-meshheading:16827112... | lld:pubmed |
| pubmed-article:16827112 | pubmed:meshHeading | pubmed-meshheading:16827112... | lld:pubmed |
| pubmed-article:16827112 | pubmed:meshHeading | pubmed-meshheading:16827112... | lld:pubmed |
| pubmed-article:16827112 | pubmed:meshHeading | pubmed-meshheading:16827112... | lld:pubmed |
| pubmed-article:16827112 | pubmed:articleTitle | Platinum (II) complexes with stereochemically-defined thiepane dioxide diamine ligands as anticancer drugs. | lld:pubmed |
| pubmed-article:16827112 | pubmed:affiliation | Department of Organic Chemistry "A. Mangini", University of Bologna, Viale Risorgimento, 4, 40136 Bologna, Italy. | lld:pubmed |
| pubmed-article:16827112 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16827112 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
