| pubmed-article:16825019 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16825019 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:16825019 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:16825019 | lifeskim:mentions | umls-concept:C0022661 | lld:lifeskim |
| pubmed-article:16825019 | lifeskim:mentions | umls-concept:C0021210 | lld:lifeskim |
| pubmed-article:16825019 | lifeskim:mentions | umls-concept:C1420141 | lld:lifeskim |
| pubmed-article:16825019 | lifeskim:mentions | umls-concept:C0552639 | lld:lifeskim |
| pubmed-article:16825019 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16825019 | pubmed:dateCreated | 2006-7-7 | lld:pubmed |
| pubmed-article:16825019 | pubmed:abstractText | Indoxyl sulfate shows nephrotoxicity and is a stimulating factor for progression of chronic renal failure (CRF). Indoxyl sulfate is taken up by renal proximal tubular cells through organic anion transporters 1 and 3 (OAT1/3), and is accumulated in the renal proximal tubular cells of uremic rats. To determine whether indoxyl sulfate is accumulated in human OAT1/3 (hOAT1/3)-positive renal proximal tubular cells, localization of indoxyl sulfate and hOAT1/3 in the kidneys of CRF patients was determined by immunohistochemistry. Kidney samples were obtained by autopsy from 9 CRF patients (mean serum creatinine 4.7 mg/dL, ranging from 2.0 to 14.5 mg/dL) and 9 patients with non-kidney disease (mean serum creatinine 0.6 mg/dL, ranging from 0.4 to 0.9 mg/dL). Immunohistochemistry was performed using antibodies against indoxyl sulfate, hOAT1, and hOAT3. Indoxyl sulfate was localized in the hOAT1- and hOAT3-positive renal tubular cells in the kidneys of CRF patients. The indoxyl sulfate-positive area in the kidneys was markedly increased in the kidneys of CRF patients compared with patients with non-kidney disease. The indoxyl sulfate-positive area was positively correlated with serum creatinine. In conclusion, in CRF patients, indoxyl sulfate is accumulated in the tubular cells with hOAT1 and/or hOAT3 localized at the basolateral membrane. The extent of indoxyl sulfate accumulation in the kidneys is more prominent in those patients with more severe CRF. | lld:pubmed |
| pubmed-article:16825019 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16825019 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16825019 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16825019 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16825019 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16825019 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16825019 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16825019 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16825019 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:16825019 | pubmed:issn | 1532-8503 | lld:pubmed |
| pubmed-article:16825019 | pubmed:author | pubmed-author:EnomotoAtsush... | lld:pubmed |
| pubmed-article:16825019 | pubmed:author | pubmed-author:NiwaToshimits... | lld:pubmed |
| pubmed-article:16825019 | pubmed:author | pubmed-author:NakamuraSakur... | lld:pubmed |
| pubmed-article:16825019 | pubmed:author | pubmed-author:TakiKentaroK | lld:pubmed |
| pubmed-article:16825019 | pubmed:author | pubmed-author:MiglinasMariu... | lld:pubmed |
| pubmed-article:16825019 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16825019 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:16825019 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16825019 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16825019 | pubmed:pagination | 199-203 | lld:pubmed |
| pubmed-article:16825019 | pubmed:meshHeading | pubmed-meshheading:16825019... | lld:pubmed |
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| pubmed-article:16825019 | pubmed:meshHeading | pubmed-meshheading:16825019... | lld:pubmed |
| pubmed-article:16825019 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16825019 | pubmed:articleTitle | Accumulation of indoxyl sulfate in OAT1/3-positive tubular cells in kidneys of patients with chronic renal failure. | lld:pubmed |
| pubmed-article:16825019 | pubmed:affiliation | Department of Clinical Preventive Medicine, Nagoya University Hospital, Nagoya, Japan. | lld:pubmed |
| pubmed-article:16825019 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16825019 | lld:pubmed |
