| pubmed-article:1682384 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1682384 | lifeskim:mentions | umls-concept:C0003315 | lld:lifeskim |
| pubmed-article:1682384 | lifeskim:mentions | umls-concept:C1423842 | lld:lifeskim |
| pubmed-article:1682384 | lifeskim:mentions | umls-concept:C1155099 | lld:lifeskim |
| pubmed-article:1682384 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:1682384 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:1682384 | pubmed:dateCreated | 1991-12-18 | lld:pubmed |
| pubmed-article:1682384 | pubmed:abstractText | We studied the capacity of macrophage and B cell lines to provide a costimulatory signal that enhances synthesis of IFN-gamma and IL-2 by mouse Th1 clones stimulated with suboptimal doses of immobilized anti-CD3 antibody. The J774 macrophage line and the CH27 B lymphoma line had the greatest costimulatory activity and routinely increased IL-2 production by 10-fold to 100-fold. Other macrophage and B cell lines had less activity and T cell lines were unable to costimulate. The J774 and CH27 lines did not costimulate IL-4 production by a Th2 clone and had only a small effect on IL-2 production by T cell hybridomas. The process of costimulation was fixation-sensitive, contact-dependent and did not involve stable cytokines present in the T cell/accessory cell conditioned media. Neutralizing antibodies for IL-1, IL-6, and TNF failed to inhibit costimulation. Antibodies to the LFA-1/ICAM-1 pair of adhesion molecules also failed to inhibit. Costimulation of IL-2 production by accessory cells was found to have a unidirectional species restriction: mouse accessory cells costimulated mouse and human IL-2-producing T cells, but human U937 cells induced with PMA were effective only for human T cells. The results indicate that accessory cells can significantly regulate Th1 effector function at the level of cytokine production. | lld:pubmed |
| pubmed-article:1682384 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1682384 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1682384 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1682384 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1682384 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1682384 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1682384 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1682384 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1682384 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:1682384 | pubmed:author | pubmed-author:WilliamsI RIR | lld:pubmed |
| pubmed-article:1682384 | pubmed:author | pubmed-author:UnanueE RER | lld:pubmed |
| pubmed-article:1682384 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1682384 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1682384 | pubmed:volume | 147 | lld:pubmed |
| pubmed-article:1682384 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1682384 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1682384 | pubmed:pagination | 3752-60 | lld:pubmed |
| pubmed-article:1682384 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1682384 | pubmed:meshHeading | pubmed-meshheading:1682384-... | lld:pubmed |
| pubmed-article:1682384 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1682384 | pubmed:articleTitle | Characterization of accessory cell costimulation of Th1 cytokine synthesis. | lld:pubmed |
| pubmed-article:1682384 | pubmed:affiliation | Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110. | lld:pubmed |
| pubmed-article:1682384 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1682384 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1682384 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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