| pubmed-article:1682155 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1682155 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1682155 | lifeskim:mentions | umls-concept:C1167395 | lld:lifeskim |
| pubmed-article:1682155 | lifeskim:mentions | umls-concept:C0814995 | lld:lifeskim |
| pubmed-article:1682155 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:1682155 | lifeskim:mentions | umls-concept:C0026189 | lld:lifeskim |
| pubmed-article:1682155 | lifeskim:mentions | umls-concept:C1868500 | lld:lifeskim |
| pubmed-article:1682155 | lifeskim:mentions | umls-concept:C1704788 | lld:lifeskim |
| pubmed-article:1682155 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:1682155 | pubmed:dateCreated | 1991-12-13 | lld:pubmed |
| pubmed-article:1682155 | pubmed:abstractText | Little is known on the effector mechanisms inducing the cutaneous lesions observed during acute graft-vs.-host disease (aGvHD) after allogeneic bone marrow transplantation (BMT). Histological findings have indicated that infiltrating CD8+ lymphocytes probably play a role. We addressed the question of whether host minor histocompatibility (mH) antigen-reactive cytotoxic T lymphocytes (CTL) could account for this phenomenon via direct lysis of the epidermal cell layer. Six CTL clones, obtained from peripheral blood lymphocytes of patients suffering from aGvHD, each recognizing a well-characterized MHC class I-restricted mH antigen epitope, were tested on cultured keratinocytes of nine MHC and mH antigen-typed donors. Four of six mH antigen-specific CTL clones lysed unstimulated MHC class I-expressing, as well as recombinant interferon-gamma (rIFN-gamma)-activated, ICAM-1, MHC class I- and II-expressing keratinocytes. Two strongly cytolytic CTL clones showed no recognition of keratinocytes of donors whose phytohemagglutinin-activated T cell lines were readily lysed. With respect to a GvHD, the results imply that some class I-restricted CTL obtained from peripheral blood lymphocytes of a GvHD patients have the in vitro potential to destroy resting as well as IFN-gamma-activated epidermal cells, whereas others do not. In other words, CTL-defined human mH antigens vary with respect to their expression in the skin. It is intriguing that those minor H antigens which cannot be detected on human keratinocytes in vitro are those known to be associated with the occurrence of GvHD. | lld:pubmed |
| pubmed-article:1682155 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1682155 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1682155 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1682155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1682155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1682155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1682155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1682155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1682155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1682155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1682155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1682155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1682155 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1682155 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1682155 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:1682155 | pubmed:author | pubmed-author:GoulmyEE | lld:pubmed |
| pubmed-article:1682155 | pubmed:author | pubmed-author:Van RoodJ JJJ | lld:pubmed |
| pubmed-article:1682155 | pubmed:author | pubmed-author:BakkerAA | lld:pubmed |
| pubmed-article:1682155 | pubmed:author | pubmed-author:De BuegerMM | lld:pubmed |
| pubmed-article:1682155 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1682155 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:1682155 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1682155 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1682155 | pubmed:pagination | 2839-44 | lld:pubmed |
| pubmed-article:1682155 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:1682155 | pubmed:meshHeading | pubmed-meshheading:1682155-... | lld:pubmed |
| pubmed-article:1682155 | pubmed:meshHeading | pubmed-meshheading:1682155-... | lld:pubmed |
| pubmed-article:1682155 | pubmed:meshHeading | pubmed-meshheading:1682155-... | lld:pubmed |
| pubmed-article:1682155 | pubmed:meshHeading | pubmed-meshheading:1682155-... | lld:pubmed |
| pubmed-article:1682155 | pubmed:meshHeading | pubmed-meshheading:1682155-... | lld:pubmed |
| pubmed-article:1682155 | pubmed:meshHeading | pubmed-meshheading:1682155-... | lld:pubmed |
| pubmed-article:1682155 | pubmed:meshHeading | pubmed-meshheading:1682155-... | lld:pubmed |
| pubmed-article:1682155 | pubmed:meshHeading | pubmed-meshheading:1682155-... | lld:pubmed |
| pubmed-article:1682155 | pubmed:meshHeading | pubmed-meshheading:1682155-... | lld:pubmed |
| pubmed-article:1682155 | pubmed:meshHeading | pubmed-meshheading:1682155-... | lld:pubmed |
| pubmed-article:1682155 | pubmed:meshHeading | pubmed-meshheading:1682155-... | lld:pubmed |
| pubmed-article:1682155 | pubmed:meshHeading | pubmed-meshheading:1682155-... | lld:pubmed |
| pubmed-article:1682155 | pubmed:meshHeading | pubmed-meshheading:1682155-... | lld:pubmed |
| pubmed-article:1682155 | pubmed:meshHeading | pubmed-meshheading:1682155-... | lld:pubmed |
| pubmed-article:1682155 | pubmed:meshHeading | pubmed-meshheading:1682155-... | lld:pubmed |
| pubmed-article:1682155 | pubmed:meshHeading | pubmed-meshheading:1682155-... | lld:pubmed |
| pubmed-article:1682155 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1682155 | pubmed:articleTitle | Minor histocompatibility antigens, defined by graft-vs.-host disease-derived cytotoxic T lymphocytes, show variable expression on human skin cells. | lld:pubmed |
| pubmed-article:1682155 | pubmed:affiliation | Department of Immunohaematology, University Hospital, Leiden, The Netherlands. | lld:pubmed |
| pubmed-article:1682155 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1682155 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1682155 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1682155 | lld:pubmed |
