| pubmed-article:16817978 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16817978 | lifeskim:mentions | umls-concept:C0003873 | lld:lifeskim |
| pubmed-article:16817978 | lifeskim:mentions | umls-concept:C0023516 | lld:lifeskim |
| pubmed-article:16817978 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:16817978 | lifeskim:mentions | umls-concept:C0666743 | lld:lifeskim |
| pubmed-article:16817978 | lifeskim:mentions | umls-concept:C0681842 | lld:lifeskim |
| pubmed-article:16817978 | lifeskim:mentions | umls-concept:C2003903 | lld:lifeskim |
| pubmed-article:16817978 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16817978 | pubmed:dateCreated | 2007-1-16 | lld:pubmed |
| pubmed-article:16817978 | pubmed:abstractText | As indicators of responsiveness to a tumour necrosis factor (TNF)alpha blocking agent (infliximab) are lacking in rheumatoid arthritis, we have used gene profiling in peripheral blood mononuclear cells to predict a good versus poor response to infliximab. Thirty three patients with very active disease (Disease Activity Score 28 >5.1) that resisted weekly methotrexate therapy were given infliximab at baseline, weeks 2 and 6, and every 8th week thereafter. The patients were categorized as responders if a change of Disease Activity Score 28 = 1.2 was obtained at 3 months. Mononuclear cell RNAs were collected at baseline and at three months from responders and non-responders. The baseline RNAs were hybridised to a microarray of 10,000 non-redundant human cDNAs. In 6 responders and 7 non-responders, 41 mRNAs identified by microarray analysis were expressed as a function of the response to treatment and an unsupervised hierarchical clustering perfectly separated these responders from non-responders. The informativeness of 20 of these 41 transcripts, as measured by qRT-PCR, was re-assessed in 20 other patients. The combined levels of these 20 transcripts properly classified 16 out of 20 patients in a leave-one-out procedure, with a sensitivity of 90% and a specificity of 70%, whereas a set of only 8 transcripts properly classified 18/20 patients. Trends for changes in various transcript levels at three months tightly correlated with treatment responsiveness and a down-regulation of specific transcript levels was observed in non-responders only. Our gene profiling obtained by a non-invasive procedure should now be used to predict the likely responders to an infliximab/methotrexate combination. | lld:pubmed |
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| pubmed-article:16817978 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16817978 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16817978 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16817978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16817978 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16817978 | pubmed:issn | 1478-6362 | lld:pubmed |
| pubmed-article:16817978 | pubmed:author | pubmed-author:TronFrançoisF | lld:pubmed |
| pubmed-article:16817978 | pubmed:author | pubmed-author:SalierJean-Ph... | lld:pubmed |
| pubmed-article:16817978 | pubmed:author | pubmed-author:DaveauMaryvon... | lld:pubmed |
| pubmed-article:16817978 | pubmed:author | pubmed-author:Le... | lld:pubmed |
| pubmed-article:16817978 | pubmed:author | pubmed-author:VittecoqOlivi... | lld:pubmed |
| pubmed-article:16817978 | pubmed:author | pubmed-author:LequerréThier... | lld:pubmed |
| pubmed-article:16817978 | pubmed:author | pubmed-author:MejjadOthmane... | lld:pubmed |
| pubmed-article:16817978 | pubmed:author | pubmed-author:DaragonAlainA | lld:pubmed |
| pubmed-article:16817978 | pubmed:author | pubmed-author:HironMartineM | lld:pubmed |
| pubmed-article:16817978 | pubmed:author | pubmed-author:DerambureCéli... | lld:pubmed |
| pubmed-article:16817978 | pubmed:author | pubmed-author:Gauthier-Jaun... | lld:pubmed |
| pubmed-article:16817978 | pubmed:author | pubmed-author:BansardCarine... | lld:pubmed |
| pubmed-article:16817978 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16817978 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:16817978 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16817978 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16817978 | pubmed:pagination | R105 | lld:pubmed |
| pubmed-article:16817978 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:16817978 | pubmed:meshHeading | pubmed-meshheading:16817978... | lld:pubmed |
| pubmed-article:16817978 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16817978 | pubmed:articleTitle | Gene profiling in white blood cells predicts infliximab responsiveness in rheumatoid arthritis. | lld:pubmed |
| pubmed-article:16817978 | pubmed:affiliation | CHU de Rouen, Hôpitaux de Rouen, Service de Rhumatologie, Rouen, F-76000, France. | lld:pubmed |
| pubmed-article:16817978 | pubmed:publicationType | Journal Article | lld:pubmed |
