A brief history of RNAi: the silence of the genes.

Source:http://linkedlifedata.com/resource/pubmed/id/16816104

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Affiliation

Department of Molecular Pharmacology, Baxter Laboratory in Genetic Pharmacology, 269 Campus Dr., CCSR 4225A, Stanford University School of Medicine, Stanford, California 94305, USA. gsen@stanford.edu

Abstract

The use of the RNA interference (RNAi) pathway to eliminate gene products has greatly facilitated the understanding of gene function. Behind this remarkable pathway is an intricate network of proteins that ensures the degradation of the target mRNA. In this review, we explore the history of RNAi as well as highlighting recent discoveries.

PMID
16816104