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pubmed-article:16809739pubmed:abstractTextAdjuvant high-dose interferon-alfa-2b (HDI) improves disease-free and overall survival in patients with high-risk melanoma. However, its mechanism of action is largely unknown. Therefore, HDI was investigated in the neoadjuvant setting to assess clinical and pathologic responses after 4 weeks of HDI and to perform immunohistochemical evaluation of immune cell subsets and melanoma-associated antigens.lld:pubmed
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pubmed-article:16809739pubmed:articleTitleNeoadjuvant treatment of regional stage IIIB melanoma with high-dose interferon alfa-2b induces objective tumor regression in association with modulation of tumor infiltrating host cellular immune responses.lld:pubmed
pubmed-article:16809739pubmed:affiliationMelanoma and Skin Cancer Program, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.lld:pubmed
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