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pubmed-article:16803615pubmed:abstractTextThe development and testing of functions for the modeling of protein energetics is an important part of current research aimed at understanding protein structure and function. Knowledge-based mean force potentials are derived from statistical analyses of interacting groups in experimentally determined protein structures. Current knowledge-based mean force potentials are developed at the atom or amino acid level. The evolutionary information contained in the profiles is not investigated. Based on these observations, a class of novel knowledge-based mean force potentials at the profile level has been presented, which uses the evolutionary information of profiles for developing more powerful statistical potentials.lld:pubmed
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pubmed-article:16803615pubmed:authorpubmed-author:XiaolongWangWlld:pubmed
pubmed-article:16803615pubmed:authorpubmed-author:DongQiwenQlld:pubmed
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