| pubmed-article:16799614 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16799614 | lifeskim:mentions | umls-concept:C0023449 | lld:lifeskim |
| pubmed-article:16799614 | lifeskim:mentions | umls-concept:C1705576 | lld:lifeskim |
| pubmed-article:16799614 | lifeskim:mentions | umls-concept:C1882454 | lld:lifeskim |
| pubmed-article:16799614 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16799614 | pubmed:dateCreated | 2006-7-19 | lld:pubmed |
| pubmed-article:16799614 | pubmed:abstractText | We explored the safety and efficacy of rituximab administered in combination with the standard transplant conditioning regimen of cyclophosphamide (Cy) 120 mg/kg and total body irradiation (TBI) 12 Gy for adult patients with acute lymphoblastic leukemia (ALL). Patients were eligible if their disease expressed CD20. Rituximab was administered at 375 mg/m2 weekly for four doses beginning on day -7 of the conditioning regimen. Graft-versus-host-disease (GVHD) prophylaxis consisted of tacrolimus and methotrexate. Thirty-five patients undergoing matched sibling (n = 23) or unrelated donor (n = 12) transplantation were studied, with a median age of 30 years (range 15-55 years). At 2 years, progression-free survival, treatment-related mortality, and overall survival were 30, 24, and 47%, respectively. There was no delay in engraftment or increased incidence of infection. The cumulative incidence of grade II-IV acute GVHD was 17%, and limited and extensive chronic GVHD was 43% at 2 years. The addition of rituximab to the standard Cy/TBI transplant conditioning regimen in ALL was safe and well tolerated, and there was a suggestion of decreased incidence of acute GVHD when compared to historically reported GVHD rates for this group of patients. | lld:pubmed |
| pubmed-article:16799614 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16799614 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16799614 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16799614 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16799614 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16799614 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16799614 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16799614 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16799614 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16799614 | pubmed:issn | 0268-3369 | lld:pubmed |
| pubmed-article:16799614 | pubmed:author | pubmed-author:IppolitoEE | lld:pubmed |
| pubmed-article:16799614 | pubmed:author | pubmed-author:MaCC | lld:pubmed |
| pubmed-article:16799614 | pubmed:author | pubmed-author:ChamplinR ERE | lld:pubmed |
| pubmed-article:16799614 | pubmed:author | pubmed-author:GiraltSS | lld:pubmed |
| pubmed-article:16799614 | pubmed:author | pubmed-author:GajewskiJ LJL | lld:pubmed |
| pubmed-article:16799614 | pubmed:author | pubmed-author:HaC SCS | lld:pubmed |
| pubmed-article:16799614 | pubmed:author | pubmed-author:KebriaeiPP | lld:pubmed |
| pubmed-article:16799614 | pubmed:author | pubmed-author:QazilbashM... | lld:pubmed |
| pubmed-article:16799614 | pubmed:author | pubmed-author:KhouriI FIF | lld:pubmed |
| pubmed-article:16799614 | pubmed:author | pubmed-author:CourielD RDR | lld:pubmed |
| pubmed-article:16799614 | pubmed:author | pubmed-author:de LimaMM | lld:pubmed |
| pubmed-article:16799614 | pubmed:author | pubmed-author:SalibaR MRM | lld:pubmed |
| pubmed-article:16799614 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16799614 | pubmed:volume | 38 | lld:pubmed |
| pubmed-article:16799614 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16799614 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16799614 | pubmed:pagination | 203-9 | lld:pubmed |
| pubmed-article:16799614 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:16799614 | pubmed:meshHeading | pubmed-meshheading:16799614... | lld:pubmed |
| pubmed-article:16799614 | pubmed:meshHeading | pubmed-meshheading:16799614... | lld:pubmed |
| pubmed-article:16799614 | pubmed:meshHeading | pubmed-meshheading:16799614... | lld:pubmed |
| pubmed-article:16799614 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16799614 | pubmed:articleTitle | Allogeneic hematopoietic stem cell transplantation after rituximab-containing myeloablative preparative regimen for acute lymphoblastic leukemia. | lld:pubmed |
| pubmed-article:16799614 | pubmed:affiliation | Department of Blood and Marrow Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. pkebriae@mdanderson.org | lld:pubmed |
| pubmed-article:16799614 | pubmed:publicationType | Journal Article | lld:pubmed |
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