| pubmed-article:1679667 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1679667 | lifeskim:mentions | umls-concept:C0011991 | lld:lifeskim |
| pubmed-article:1679667 | lifeskim:mentions | umls-concept:C0004900 | lld:lifeskim |
| pubmed-article:1679667 | lifeskim:mentions | umls-concept:C0243192 | lld:lifeskim |
| pubmed-article:1679667 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:1679667 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:1679667 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1679667 | pubmed:dateCreated | 1991-10-17 | lld:pubmed |
| pubmed-article:1679667 | pubmed:abstractText | The effects of systemic administration of alpha 2-adrenoceptor agonists on migrating myoelectric complexes and castor oil-induced diarrhoea of the small intestine were studied in conscious rats. Castor oil (1 mg/kg, intraduodenally) disrupted the migrating myoelectric complexes and induced irregular spiking activity with sporadic bursts of myoelectric activity. This change of motility pattern was present concomitant with diarrhoea 1-2 h after instillation of castor oil and during the whole period of diarrhoea. Pre-treatment with clonidine (5-10 micrograms/kg i.v.) or oxymetazoline (5.6-11.2 micrograms/kg i.v.), a peripherally active alpha 2-agonist, inhibited the irregular spiking induced by castor oil and no diarrhoea occurred during the experimental period of 6 h. Thus, the antidiarrhoeal action of peripherally acting alpha 2-adrenoceptor agonists such as oxymetazoline, may be of clinical value in the treatment of diarrhoea. | lld:pubmed |
| pubmed-article:1679667 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1679667 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1679667 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1679667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1679667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1679667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1679667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1679667 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1679667 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1679667 | pubmed:issn | 0269-2813 | lld:pubmed |
| pubmed-article:1679667 | pubmed:author | pubmed-author:SvenssonT HTH | lld:pubmed |
| pubmed-article:1679667 | pubmed:author | pubmed-author:HellströmP... | lld:pubmed |
| pubmed-article:1679667 | pubmed:author | pubmed-author:ThollanderMM | lld:pubmed |
| pubmed-article:1679667 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1679667 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:1679667 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1679667 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1679667 | pubmed:pagination | 255-62 | lld:pubmed |
| pubmed-article:1679667 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1679667 | pubmed:meshHeading | pubmed-meshheading:1679667-... | lld:pubmed |
| pubmed-article:1679667 | pubmed:meshHeading | pubmed-meshheading:1679667-... | lld:pubmed |
| pubmed-article:1679667 | pubmed:meshHeading | pubmed-meshheading:1679667-... | lld:pubmed |
| pubmed-article:1679667 | pubmed:meshHeading | pubmed-meshheading:1679667-... | lld:pubmed |
| pubmed-article:1679667 | pubmed:meshHeading | pubmed-meshheading:1679667-... | lld:pubmed |
| pubmed-article:1679667 | pubmed:meshHeading | pubmed-meshheading:1679667-... | lld:pubmed |
| pubmed-article:1679667 | pubmed:meshHeading | pubmed-meshheading:1679667-... | lld:pubmed |
| pubmed-article:1679667 | pubmed:meshHeading | pubmed-meshheading:1679667-... | lld:pubmed |
| pubmed-article:1679667 | pubmed:meshHeading | pubmed-meshheading:1679667-... | lld:pubmed |
| pubmed-article:1679667 | pubmed:meshHeading | pubmed-meshheading:1679667-... | lld:pubmed |
| pubmed-article:1679667 | pubmed:meshHeading | pubmed-meshheading:1679667-... | lld:pubmed |
| pubmed-article:1679667 | pubmed:meshHeading | pubmed-meshheading:1679667-... | lld:pubmed |
| pubmed-article:1679667 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1679667 | pubmed:articleTitle | Suppression of castor oil-induced diarrhoea by alpha 2-adrenoceptor agonists. | lld:pubmed |
| pubmed-article:1679667 | pubmed:affiliation | Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden. | lld:pubmed |
| pubmed-article:1679667 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1679667 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1679667 | lld:pubmed |
