| pubmed-article:16793916 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16793916 | lifeskim:mentions | umls-concept:C1445421 | lld:lifeskim |
| pubmed-article:16793916 | lifeskim:mentions | umls-concept:C1167395 | lld:lifeskim |
| pubmed-article:16793916 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:16793916 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:16793916 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:16793916 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:16793916 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:16793916 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:16793916 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:16793916 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:16793916 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:16793916 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:16793916 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:16793916 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:16793916 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:16793916 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:16793916 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16793916 | pubmed:dateCreated | 2006-8-30 | lld:pubmed |
| pubmed-article:16793916 | pubmed:abstractText | Invasive aspergillosis is a major cause of morbidity and mortality in the severely immunocompromised. The paucity of information about the mechanisms by which Aspergillus-derived factors regulate antigen-specific T cell responses in vivo poses a significant hurdle for devising effective immunization strategies to treat or prevent aspergillosis. By monitoring adoptively transferred T cell receptor transgenic, naive CD4+ (OT-II) and CD8+ (OT-I) T cells specific for distinct peptides of a nominal antigen, chicken ovalbumin (OVA), we demonstrate that sensitization with Aspergillus fumigatus (Af) extract plus OVA protein considerably enhances OT-I and OT-II T cell activation, which results in clonal expansion, primarily as a result of increased proliferation. The sensitization provided by Af extract promotes OT-I expansion accompanied by differentiation into interferon-gamma-producing cytotoxic cells. It is surprising that no effector differentiation of the induced OT-II response was observed. Moreover, the Af extract-induced OT-I and OT-II T cell expansion was transient, as considerable contraction in the numbers of detectable OT-I and OT-II T cells was evidenced by Day 10. In agreement with these observations, sensitization with Af extract plus OVA marginally promoted host immunity against an OVA-expressing thymoma (E.G7) challenge, and the protection was enhanced by resensitization with Af extract and OVA. Our results demonstrate the ability of Af extract to differentially regulate antigen-specific CD4+ and CD8+ T cell responses, resulting in limited augmentation of host immunity. This information suggests that strategies to target CD4+ T cell effector maturation may promote host immunity to Aspergillus and unexpectedly demonstrates the use for Af extract as a CD8+ T cell adjuvant. | lld:pubmed |
| pubmed-article:16793916 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16793916 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16793916 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16793916 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16793916 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16793916 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16793916 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16793916 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16793916 | pubmed:issn | 0741-5400 | lld:pubmed |
| pubmed-article:16793916 | pubmed:author | pubmed-author:SegalBrahm... | lld:pubmed |
| pubmed-article:16793916 | pubmed:author | pubmed-author:TaoJianmingJ | lld:pubmed |
| pubmed-article:16793916 | pubmed:author | pubmed-author:LiQingshengQ | lld:pubmed |
| pubmed-article:16793916 | pubmed:author | pubmed-author:ShrikantProtu... | lld:pubmed |
| pubmed-article:16793916 | pubmed:author | pubmed-author:EppolitoChery... | lld:pubmed |
| pubmed-article:16793916 | pubmed:author | pubmed-author:YounRichardR | lld:pubmed |
| pubmed-article:16793916 | pubmed:author | pubmed-author:DennisCarly... | lld:pubmed |
| pubmed-article:16793916 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16793916 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:16793916 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16793916 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16793916 | pubmed:pagination | 529-37 | lld:pubmed |
| pubmed-article:16793916 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
| pubmed-article:16793916 | pubmed:meshHeading | pubmed-meshheading:16793916... | lld:pubmed |
| pubmed-article:16793916 | pubmed:meshHeading | pubmed-meshheading:16793916... | lld:pubmed |
| pubmed-article:16793916 | pubmed:meshHeading | pubmed-meshheading:16793916... | lld:pubmed |
| pubmed-article:16793916 | pubmed:meshHeading | pubmed-meshheading:16793916... | lld:pubmed |
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| pubmed-article:16793916 | pubmed:meshHeading | pubmed-meshheading:16793916... | lld:pubmed |
| pubmed-article:16793916 | pubmed:meshHeading | pubmed-meshheading:16793916... | lld:pubmed |
| pubmed-article:16793916 | pubmed:meshHeading | pubmed-meshheading:16793916... | lld:pubmed |
| pubmed-article:16793916 | pubmed:meshHeading | pubmed-meshheading:16793916... | lld:pubmed |
| pubmed-article:16793916 | pubmed:meshHeading | pubmed-meshheading:16793916... | lld:pubmed |
| pubmed-article:16793916 | pubmed:meshHeading | pubmed-meshheading:16793916... | lld:pubmed |
| pubmed-article:16793916 | pubmed:meshHeading | pubmed-meshheading:16793916... | lld:pubmed |
| pubmed-article:16793916 | pubmed:meshHeading | pubmed-meshheading:16793916... | lld:pubmed |
| pubmed-article:16793916 | pubmed:meshHeading | pubmed-meshheading:16793916... | lld:pubmed |
| pubmed-article:16793916 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16793916 | pubmed:articleTitle | Aspergillus fumigatus extract differentially regulates antigen-specific CD4+ and CD8+ T cell responses to promote host immunity. | lld:pubmed |
| pubmed-article:16793916 | pubmed:affiliation | Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA. | lld:pubmed |
| pubmed-article:16793916 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16793916 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16793916 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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