| pubmed-article:16793273 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16793273 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:16793273 | lifeskim:mentions | umls-concept:C1817671 | lld:lifeskim |
| pubmed-article:16793273 | lifeskim:mentions | umls-concept:C0043481 | lld:lifeskim |
| pubmed-article:16793273 | lifeskim:mentions | umls-concept:C0678558 | lld:lifeskim |
| pubmed-article:16793273 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:16793273 | pubmed:dateCreated | 2006-7-19 | lld:pubmed |
| pubmed-article:16793273 | pubmed:abstractText | Chemical synapses are asymmetric cell junctions that mediate communication between neurons. Multidomain scaffolding proteins of the Shank family act as major organizing elements of the "postsynaptic density"--that is, the cytoskeletal protein matrix associated with the postsynaptic membrane. A recent study has shown that the C-terminal sterile alpha-motif or "SAM domain" of Shank3 (also known as ProSAP2) can form two-dimensional sheets of helical fibers. Assembly and packaging of these fibers are markedly enhanced by the presence of Zn2+ ions. Zn2+ can be released together with glutamate from synaptic vesicles and can enter the postsynaptic cell through specific ionotropic receptors. Based on these observations, we propose a new model of synaptic plasticity in which Zn2+ influx directly and instantly modulates the structure and function of the postsynaptic density. | lld:pubmed |
| pubmed-article:16793273 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16793273 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16793273 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16793273 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16793273 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16793273 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16793273 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16793273 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16793273 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16793273 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16793273 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16793273 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:16793273 | pubmed:issn | 0968-0004 | lld:pubmed |
| pubmed-article:16793273 | pubmed:author | pubmed-author:GundelfingerE... | lld:pubmed |
| pubmed-article:16793273 | pubmed:author | pubmed-author:BowieJames... | lld:pubmed |
| pubmed-article:16793273 | pubmed:author | pubmed-author:BoeckersTobia... | lld:pubmed |
| pubmed-article:16793273 | pubmed:author | pubmed-author:BaronMarisa... | lld:pubmed |
| pubmed-article:16793273 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16793273 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:16793273 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16793273 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16793273 | pubmed:pagination | 366-73 | lld:pubmed |
| pubmed-article:16793273 | pubmed:dateRevised | 2009-8-18 | lld:pubmed |
| pubmed-article:16793273 | pubmed:meshHeading | pubmed-meshheading:16793273... | lld:pubmed |
| pubmed-article:16793273 | pubmed:meshHeading | pubmed-meshheading:16793273... | lld:pubmed |
| pubmed-article:16793273 | pubmed:meshHeading | pubmed-meshheading:16793273... | lld:pubmed |
| pubmed-article:16793273 | pubmed:meshHeading | pubmed-meshheading:16793273... | lld:pubmed |
| pubmed-article:16793273 | pubmed:meshHeading | pubmed-meshheading:16793273... | lld:pubmed |
| pubmed-article:16793273 | pubmed:meshHeading | pubmed-meshheading:16793273... | lld:pubmed |
| pubmed-article:16793273 | pubmed:meshHeading | pubmed-meshheading:16793273... | lld:pubmed |
| pubmed-article:16793273 | pubmed:meshHeading | pubmed-meshheading:16793273... | lld:pubmed |
| pubmed-article:16793273 | pubmed:meshHeading | pubmed-meshheading:16793273... | lld:pubmed |
| pubmed-article:16793273 | pubmed:meshHeading | pubmed-meshheading:16793273... | lld:pubmed |
| pubmed-article:16793273 | pubmed:meshHeading | pubmed-meshheading:16793273... | lld:pubmed |
| pubmed-article:16793273 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16793273 | pubmed:articleTitle | A role for zinc in postsynaptic density asSAMbly and plasticity? | lld:pubmed |
| pubmed-article:16793273 | pubmed:affiliation | Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118 Magdeburg, Germany. gundelfinger@ifn-magdeburg.de | lld:pubmed |
| pubmed-article:16793273 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16793273 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16793273 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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