| pubmed-article:16791879 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16791879 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:16791879 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:16791879 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:16791879 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:16791879 | lifeskim:mentions | umls-concept:C1121402 | lld:lifeskim |
| pubmed-article:16791879 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:16791879 | lifeskim:mentions | umls-concept:C0023273 | lld:lifeskim |
| pubmed-article:16791879 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:16791879 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:16791879 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:16791879 | pubmed:dateCreated | 2006-8-7 | lld:pubmed |
| pubmed-article:16791879 | pubmed:abstractText | Adoptive dendritic cell (DC) immunotherapy provides a useful experimental tool to evaluate immunoregulation in vivo and has previously been successfully used to enhance host resistance in a variety of experimental models of leishmaniasis. Here, we used this approach to identify IL-6 and IL-12p40 as critical cytokines that cooperate to mediate host protection to Leishmania donovani but which act independently to regulate expansion of IL-10(+) CD4(+) T cells, shown here for the first time to be associated with this infection. Adoptive transfer of LPS-activated bone marrow-derived DC (BMDC) from wild-type mice was therapeutically beneficial and led to enhanced resistance as measured by spleen parasite burden. In contrast, IL-6- or IL-12p40-deficient BMDC had no protective benefit, indicating that production of both cytokines was essential for the therapeutic efficacy of DC. IL-10 production by CD25(-) FoxP3(-) IL-10(+) CD4(+) T cells is a strong correlate of disease progression, and BMDC from wild-type mice inhibited expansion of these cells. Strikingly, IL-12-deficient BMDC could also inhibit the expansion of this T cell population whereas IL-6-deficient BMDC could not, indicating that IL-6 played a key role in this aspect of DC function in vivo. Breadth of cytokine production is thus an important factor when considering strategies for DC-based interventions. | lld:pubmed |
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| pubmed-article:16791879 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16791879 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16791879 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16791879 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16791879 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:16791879 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:16791879 | pubmed:author | pubmed-author:KopfManfredM | lld:pubmed |
| pubmed-article:16791879 | pubmed:author | pubmed-author:KayePaul MPM | lld:pubmed |
| pubmed-article:16791879 | pubmed:author | pubmed-author:SanosStephani... | lld:pubmed |
| pubmed-article:16791879 | pubmed:author | pubmed-author:StägerSimonaS | lld:pubmed |
| pubmed-article:16791879 | pubmed:author | pubmed-author:ZubairiSoombu... | lld:pubmed |
| pubmed-article:16791879 | pubmed:author | pubmed-author:MaroofAsherA | lld:pubmed |
| pubmed-article:16791879 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16791879 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:16791879 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16791879 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16791879 | pubmed:pagination | 1764-71 | lld:pubmed |
| pubmed-article:16791879 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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