| pubmed-article:1679041 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1679041 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:1679041 | lifeskim:mentions | umls-concept:C0037993 | lld:lifeskim |
| pubmed-article:1679041 | lifeskim:mentions | umls-concept:C0036317 | lld:lifeskim |
| pubmed-article:1679041 | lifeskim:mentions | umls-concept:C1423842 | lld:lifeskim |
| pubmed-article:1679041 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:1679041 | lifeskim:mentions | umls-concept:C1518062 | lld:lifeskim |
| pubmed-article:1679041 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:1679041 | pubmed:dateCreated | 1991-10-2 | lld:pubmed |
| pubmed-article:1679041 | pubmed:abstractText | Recent studies indicate that egg granuloma formation in murine Schistosoma mansoni infection is associated with Th2-mediated immune responses. The present study was designed to analyze dynamically the Th1 and Th2 responses in S. japonicum-infected animals and compare them with the results seen with S. mansoni. C3H mice were infected with 10 to 20 cercariae of S. japonicum and sacrificed 3 to 22 weeks later. Spleen cells were stimulated with parasite antigens (egg and adult worm) or the mitogen concanavalin A. Interleukin-2 (IL-2), IL-4, IL-5, and gamma interferon (IFN-gamma) levels were measured in the culture supernatants by enzyme-linked immunosorbent assay (ELISA) or bioassays. Additionally, cytokine-producing cells were enumerated by ELISPOT. The results show that Th2 cytokine production, characterized by IL-4 and IL-5, represents the major response in the first month after egg laying begins, while the Th1 functions of IFN-gamma and IL-2 production are greatly depressed. However, by 22 weeks Th2 responses have diminished and IFN-gamma production in response to concanavalin A is apparent. IL-2 responses are minimal at all times. In vitro depletion of T-cell subsets indicates that CD4+ cells are the major subset responsible for production of IL-5 at 7 weeks of infection. These findings suggest that, as in the case of S. mansoni infection, S. japonicum-induced immunopathology is temporally associated with the host Th2 response, although other experiments indicate that IFN-gamma is also involved. | lld:pubmed |
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| pubmed-article:1679041 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1679041 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1679041 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1679041 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1679041 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1679041 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:1679041 | pubmed:author | pubmed-author:SherAA | lld:pubmed |
| pubmed-article:1679041 | pubmed:author | pubmed-author:CheeverA WAW | lld:pubmed |
| pubmed-article:1679041 | pubmed:author | pubmed-author:PearceEE | lld:pubmed |
| pubmed-article:1679041 | pubmed:author | pubmed-author:YUY GYG | lld:pubmed |
| pubmed-article:1679041 | pubmed:author | pubmed-author:MacedoniaJJ | lld:pubmed |
| pubmed-article:1679041 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1679041 | pubmed:volume | 59 | lld:pubmed |
| pubmed-article:1679041 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1679041 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1679041 | pubmed:pagination | 2934-40 | lld:pubmed |
| pubmed-article:1679041 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1679041 | pubmed:meshHeading | pubmed-meshheading:1679041-... | lld:pubmed |
| pubmed-article:1679041 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1679041 | pubmed:articleTitle | Dynamic analysis of splenic Th1 and Th2 lymphocyte functions in mice infected with Schistosoma japonicum. | lld:pubmed |
| pubmed-article:1679041 | pubmed:affiliation | Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892. | lld:pubmed |
| pubmed-article:1679041 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1679041 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1679041 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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