| pubmed-article:16790058 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16790058 | lifeskim:mentions | umls-concept:C0003250 | lld:lifeskim |
| pubmed-article:16790058 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:16790058 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:16790058 | lifeskim:mentions | umls-concept:C1513371 | lld:lifeskim |
| pubmed-article:16790058 | lifeskim:mentions | umls-concept:C0917728 | lld:lifeskim |
| pubmed-article:16790058 | lifeskim:mentions | umls-concept:C1707271 | lld:lifeskim |
| pubmed-article:16790058 | pubmed:dateCreated | 2006-8-11 | lld:pubmed |
| pubmed-article:16790058 | pubmed:abstractText | To further our understanding of the structure and function of HIV-1 integrase (IN) we developed and characterized a library of monoclonal antibodies (mAbs) directed against this protein. One of these antibodies, mAb33, which is specific for the C-terminal domain, was found to inhibit HIV-1 IN processing activity in vitro; a corresponding Fv fragment was able to inhibit HIV-1 integration in vivo. Our subsequent studies, using heteronuclear nuclear magnetic resonance spectroscopy, identified six solvent accessible residues on the surface of the C-terminal domain that were immobilized upon binding of the antibody, which were proposed to comprise the epitope. Here we test this hypothesis by measuring the affinity of mAb33 to HIV-1 proteins that contain Ala substitutions in each of these positions. To gain additional insight into the mode of inhibition we also measured the DNA binding capacity and enzymatic activities of the Ala substituted proteins. | lld:pubmed |
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| pubmed-article:16790058 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16790058 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16790058 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16790058 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16790058 | pubmed:issn | 1742-4690 | lld:pubmed |
| pubmed-article:16790058 | pubmed:author | pubmed-author:AndrakeMark... | lld:pubmed |
| pubmed-article:16790058 | pubmed:author | pubmed-author:SkalkaAnna... | lld:pubmed |
| pubmed-article:16790058 | pubmed:author | pubmed-author:RamcharanJose... | lld:pubmed |
| pubmed-article:16790058 | pubmed:author | pubmed-author:MerkelGeorgeG | lld:pubmed |
| pubmed-article:16790058 | pubmed:author | pubmed-author:ColleluoriDia... | lld:pubmed |
| pubmed-article:16790058 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16790058 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:16790058 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16790058 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16790058 | pubmed:pagination | 34 | lld:pubmed |
| pubmed-article:16790058 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:16790058 | pubmed:meshHeading | pubmed-meshheading:16790058... | lld:pubmed |
| pubmed-article:16790058 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16790058 | pubmed:articleTitle | Mode of inhibition of HIV-1 Integrase by a C-terminal domain-specific monoclonal antibody. | lld:pubmed |
| pubmed-article:16790058 | pubmed:affiliation | The Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA. JRamcharan@locuspharma.com | lld:pubmed |
| pubmed-article:16790058 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16790058 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16790058 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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