pubmed-article:16785503 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:16785503 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
pubmed-article:16785503 | lifeskim:mentions | umls-concept:C0162832 | lld:lifeskim |
pubmed-article:16785503 | lifeskim:mentions | umls-concept:C2350466 | lld:lifeskim |
pubmed-article:16785503 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
pubmed-article:16785503 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
pubmed-article:16785503 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
pubmed-article:16785503 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:16785503 | pubmed:dateCreated | 2006-6-20 | lld:pubmed |
pubmed-article:16785503 | pubmed:abstractText | Overwhelming infection remains the leading cause of death from serious burn injury despite recent advances in the care of burn patients and a better understanding of immune and inflammatory consequences of injury. In this study, we report a critical requirement for CD1d-restricted NKT cells and CD1d expression by APCs in the immune dysfunction that occurs early after burn injury. Using a well-established murine scald injury model with BALB/c and BALB/c CD1d knockout mice, we investigated whether peripheral T cell immunity was affected by the presence or absence of CD1d-restricted NKT cells in the early stages after injury. Using Ag-specific delayed-type hypersensitivity, T cell proliferation, and cytokine production as indices of immune responsiveness, we observed that both CD1d expression by APCs and CD1d-restricted NKT cells are required for immune suppression after injury. Via adoptive transfer of splenocytes from injured mice to uninjured recipients, we found injury-induced suppression of immunity to be Ag specific, long lasting, and critically dependent on cell surface expression of CD1d by APCs. Together, our results suggest that the defects in T cell responsiveness that occur subsequent to severe burn injury are not merely the result of global or passive suppression, but instead represent an active form of CD1d/NKT cell-dependent immunologic tolerance. | lld:pubmed |
pubmed-article:16785503 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:16785503 | pubmed:language | eng | lld:pubmed |
pubmed-article:16785503 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:16785503 | pubmed:citationSubset | AIM | lld:pubmed |
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pubmed-article:16785503 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:16785503 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:16785503 | pubmed:month | Jul | lld:pubmed |
pubmed-article:16785503 | pubmed:issn | 0022-1767 | lld:pubmed |
pubmed-article:16785503 | pubmed:author | pubmed-author:TaniguchiMasa... | lld:pubmed |
pubmed-article:16785503 | pubmed:author | pubmed-author:GamelliRichar... | lld:pubmed |
pubmed-article:16785503 | pubmed:author | pubmed-author:KovacsElizabe... | lld:pubmed |
pubmed-article:16785503 | pubmed:author | pubmed-author:FaunceDouglas... | lld:pubmed |
pubmed-article:16785503 | pubmed:author | pubmed-author:PalmerJessica... | lld:pubmed |
pubmed-article:16785503 | pubmed:author | pubmed-author:TulleyJulia... | lld:pubmed |
pubmed-article:16785503 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:16785503 | pubmed:day | 1 | lld:pubmed |
pubmed-article:16785503 | pubmed:volume | 177 | lld:pubmed |
pubmed-article:16785503 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:16785503 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:16785503 | pubmed:pagination | 92-9 | lld:pubmed |
pubmed-article:16785503 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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pubmed-article:16785503 | pubmed:year | 2006 | lld:pubmed |
pubmed-article:16785503 | pubmed:articleTitle | Injury-induced suppression of effector T cell immunity requires CD1d-positive APCs and CD1d-restricted NKT cells. | lld:pubmed |
pubmed-article:16785503 | pubmed:affiliation | Department of Surgery, and Burn and Shock Trauma Institute, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA. | lld:pubmed |
pubmed-article:16785503 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:16785503 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
pubmed-article:16785503 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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