| pubmed-article:1678399 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1678399 | lifeskim:mentions | umls-concept:C0019699 | lld:lifeskim |
| pubmed-article:1678399 | lifeskim:mentions | umls-concept:C0237401 | lld:lifeskim |
| pubmed-article:1678399 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:1678399 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:1678399 | lifeskim:mentions | umls-concept:C0486959 | lld:lifeskim |
| pubmed-article:1678399 | lifeskim:mentions | umls-concept:C0439165 | lld:lifeskim |
| pubmed-article:1678399 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1678399 | pubmed:dateCreated | 1991-9-16 | lld:pubmed |
| pubmed-article:1678399 | pubmed:abstractText | Human immunodeficiency virus type 1 (HIV-1) infects predominantly CD4+ cells in human peripheral blood and infection is associated with CD4+ lymphocyte dysfunction in patients with AIDS. To determine the frequency of HIV-1 infection in CD4+ lymphocytes in vivo, peripheral blood CD4+ lymphocytes were isolated by fluorescence-activated cell sorting from HIV-1-infected persons with clinical disease ranging from asymptomatic to AIDS. Using standard and booster polymerase chain reaction analyses, study patients with AIDS and AIDS-related complex (ARC) were found to harbor the HIV-1 genome in at least 10% of CD4+ lymphocytes, and approximately 10-fold less infected cells were found in those with asymptomatic infection. In addition, the peripheral blood mononuclear cells from patients with ARC frequently contained a higher absolute number of HIV-1-infected CD4+ lymphocytes than those with AIDS or asymptomatic infection. It is likely that this high level of infection of CD4+ lymphocytes is the primary cause for the progressive immunologic deficiency observed in patients infected with HIV-1. | lld:pubmed |
| pubmed-article:1678399 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1678399 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1678399 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1678399 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1678399 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1678399 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1678399 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1678399 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1678399 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1678399 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:1678399 | pubmed:author | pubmed-author:SpectorS ASA | lld:pubmed |
| pubmed-article:1678399 | pubmed:author | pubmed-author:HsiaKK | lld:pubmed |
| pubmed-article:1678399 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1678399 | pubmed:volume | 164 | lld:pubmed |
| pubmed-article:1678399 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1678399 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1678399 | pubmed:pagination | 470-5 | lld:pubmed |
| pubmed-article:1678399 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1678399 | pubmed:meshHeading | pubmed-meshheading:1678399-... | lld:pubmed |
| pubmed-article:1678399 | pubmed:meshHeading | pubmed-meshheading:1678399-... | lld:pubmed |
| pubmed-article:1678399 | pubmed:meshHeading | pubmed-meshheading:1678399-... | lld:pubmed |
| pubmed-article:1678399 | pubmed:meshHeading | pubmed-meshheading:1678399-... | lld:pubmed |
| pubmed-article:1678399 | pubmed:meshHeading | pubmed-meshheading:1678399-... | lld:pubmed |
| pubmed-article:1678399 | pubmed:meshHeading | pubmed-meshheading:1678399-... | lld:pubmed |
| pubmed-article:1678399 | pubmed:meshHeading | pubmed-meshheading:1678399-... | lld:pubmed |
| pubmed-article:1678399 | pubmed:meshHeading | pubmed-meshheading:1678399-... | lld:pubmed |
| pubmed-article:1678399 | pubmed:meshHeading | pubmed-meshheading:1678399-... | lld:pubmed |
| pubmed-article:1678399 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1678399 | pubmed:articleTitle | Human immunodeficiency virus DNA is present in a high percentage of CD4+ lymphocytes of seropositive individuals. | lld:pubmed |
| pubmed-article:1678399 | pubmed:affiliation | Department of Pediatrics, University of California, San Diego 92103. | lld:pubmed |
| pubmed-article:1678399 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1678399 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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