| pubmed-article:16782779 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16782779 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:16782779 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16782779 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:16782779 | lifeskim:mentions | umls-concept:C0023903 | lld:lifeskim |
| pubmed-article:16782779 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:16782779 | lifeskim:mentions | umls-concept:C0041370 | lld:lifeskim |
| pubmed-article:16782779 | lifeskim:mentions | umls-concept:C1707391 | lld:lifeskim |
| pubmed-article:16782779 | lifeskim:mentions | umls-concept:C0207004 | lld:lifeskim |
| pubmed-article:16782779 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16782779 | pubmed:dateCreated | 2006-8-8 | lld:pubmed |
| pubmed-article:16782779 | pubmed:abstractText | Polychlorinated biphenyls (PCBs) are ubiquitous environmental toxicants which act as liver tumor promoters in rodents and can be classified as either dioxin-like or non-dioxin (phenobarbital [PB])-like inducers of cytochrome P-450. Since we have previously shown that tumor promotion by PB leads to clonal outgrowth of beta-catenin (Catnb)-mutated but not Ha-ras-mutated mouse liver tumors, we were interested to know whether the non-dioxin-like tumor promoter 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) shows the same selective pressure during tumor promotion. Male B6129SF2/J mice were given a single injection of N-nitrosodiethylamine (90 mg/kg body weight) at 9 weeks of age, followed by 39 weeks of treatment with PCB 153 (20 biweekly ip injections of 300 mumol/kg body weight) or corn oil as a control. Animals were killed 15 weeks after the last PCB 153 injection and liver tumors were identified by immunohistochemical staining of glutamine synthetase (GS) and analyzed for Catnb, Ha-ras, and B-raf mutations. Quantitative analyses revealed that GS-positive tumors were much larger and more frequent in livers from PCB 153-treated mice than in control animals, whereas GS-negative tumors were similar in both groups. Almost 90% (34/38) of all tumors from PCB 153-treated animals contained Catnb mutations, which compares to approximately 45% (17/37) of tumors in the control group. Ha-ras- and B-raf-mutated liver tumors were rare and not significantly different between treatment groups. These results clearly indicate that PCB 153 strongly selects for Catnb-mutated, GS-positive liver tumors, which is similar to the known action of PB, a prototypical tumor promoter in rodent liver. | lld:pubmed |
| pubmed-article:16782779 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16782779 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16782779 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16782779 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16782779 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16782779 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16782779 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16782779 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16782779 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16782779 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16782779 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16782779 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16782779 | pubmed:issn | 1096-6080 | lld:pubmed |
| pubmed-article:16782779 | pubmed:author | pubmed-author:RobertsonLarr... | lld:pubmed |
| pubmed-article:16782779 | pubmed:author | pubmed-author:SchwarzMichae... | lld:pubmed |
| pubmed-article:16782779 | pubmed:author | pubmed-author:TharappelJob... | lld:pubmed |
| pubmed-article:16782779 | pubmed:author | pubmed-author:SpearBrett... | lld:pubmed |
| pubmed-article:16782779 | pubmed:author | pubmed-author:GlauertHoward... | lld:pubmed |
| pubmed-article:16782779 | pubmed:author | pubmed-author:BuchmannAlbre... | lld:pubmed |
| pubmed-article:16782779 | pubmed:author | pubmed-author:AppelKlaus... | lld:pubmed |
| pubmed-article:16782779 | pubmed:author | pubmed-author:StrathmannJul... | lld:pubmed |
| pubmed-article:16782779 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16782779 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:16782779 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16782779 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16782779 | pubmed:pagination | 34-40 | lld:pubmed |
| pubmed-article:16782779 | pubmed:dateRevised | 2010-9-17 | lld:pubmed |
| pubmed-article:16782779 | pubmed:meshHeading | pubmed-meshheading:16782779... | lld:pubmed |
| pubmed-article:16782779 | pubmed:meshHeading | pubmed-meshheading:16782779... | lld:pubmed |
| pubmed-article:16782779 | pubmed:meshHeading | pubmed-meshheading:16782779... | lld:pubmed |
| pubmed-article:16782779 | pubmed:meshHeading | pubmed-meshheading:16782779... | lld:pubmed |
| pubmed-article:16782779 | pubmed:meshHeading | pubmed-meshheading:16782779... | lld:pubmed |
| pubmed-article:16782779 | pubmed:meshHeading | pubmed-meshheading:16782779... | lld:pubmed |
| pubmed-article:16782779 | pubmed:meshHeading | pubmed-meshheading:16782779... | lld:pubmed |
| pubmed-article:16782779 | pubmed:meshHeading | pubmed-meshheading:16782779... | lld:pubmed |
| pubmed-article:16782779 | pubmed:meshHeading | pubmed-meshheading:16782779... | lld:pubmed |
| pubmed-article:16782779 | pubmed:meshHeading | pubmed-meshheading:16782779... | lld:pubmed |
| pubmed-article:16782779 | pubmed:meshHeading | pubmed-meshheading:16782779... | lld:pubmed |
| pubmed-article:16782779 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16782779 | pubmed:articleTitle | PCB 153, a non-dioxin-like tumor promoter, selects for beta-catenin (Catnb)-mutated mouse liver tumors. | lld:pubmed |
| pubmed-article:16782779 | pubmed:affiliation | Department of Toxicology, University of Tuebingen, 72074 Tuebingen, Germany. | lld:pubmed |
| pubmed-article:16782779 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16782779 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:16782779 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16782779 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16782779 | lld:pubmed |
