| pubmed-article:1678132 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1678132 | lifeskim:mentions | umls-concept:C0042960 | lld:lifeskim |
| pubmed-article:1678132 | lifeskim:mentions | umls-concept:C1549078 | lld:lifeskim |
| pubmed-article:1678132 | lifeskim:mentions | umls-concept:C1997894 | lld:lifeskim |
| pubmed-article:1678132 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:1678132 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:1678132 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:1678132 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1678132 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:1678132 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:1678132 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:1678132 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:1678132 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:1678132 | pubmed:dateCreated | 1991-9-12 | lld:pubmed |
| pubmed-article:1678132 | pubmed:abstractText | Platelet and lymphocyte adrenoceptor binding was measured in 12 healthy male volunteers before and after 22 days treatment with the alpha 2-adrenoceptor antagonist idazoxan 40 mg tds. Platelet alpha 2-adrenoceptor number assessed by the agonist 3H-UK 14304 [correction of UK 14303] was significantly increased following idazoxan, with a smaller increase in antagonist binding (3H-rauwolscine). Lymphocyte beta-adrenoceptor number was unaltered by idazoxan, although the variance within the sample was significantly increased. Plasma MHPG levels were significantly reduced by chronic idazoxan. These data indicate upregulation of the platelet alpha 2-adrenoceptor in response to chronic blockade and suggest that this may reflect a similar change in presynaptic alpha 2-adrenoceptors which regulate norepinephrine release. | lld:pubmed |
| pubmed-article:1678132 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1678132 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1678132 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1678132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1678132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1678132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1678132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1678132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1678132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1678132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1678132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1678132 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1678132 | pubmed:issn | 0024-3205 | lld:pubmed |
| pubmed-article:1678132 | pubmed:author | pubmed-author:ElliottJ MJM | lld:pubmed |
| pubmed-article:1678132 | pubmed:author | pubmed-author:KayGG | lld:pubmed |
| pubmed-article:1678132 | pubmed:author | pubmed-author:NuttD JDJ | lld:pubmed |
| pubmed-article:1678132 | pubmed:author | pubmed-author:GluePP | lld:pubmed |
| pubmed-article:1678132 | pubmed:author | pubmed-author:PayvandiNN | lld:pubmed |
| pubmed-article:1678132 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1678132 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:1678132 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1678132 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1678132 | pubmed:pagination | PL21-5 | lld:pubmed |
| pubmed-article:1678132 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:1678132 | pubmed:meshHeading | pubmed-meshheading:1678132-... | lld:pubmed |
| pubmed-article:1678132 | pubmed:meshHeading | pubmed-meshheading:1678132-... | lld:pubmed |
| pubmed-article:1678132 | pubmed:meshHeading | pubmed-meshheading:1678132-... | lld:pubmed |
| pubmed-article:1678132 | pubmed:meshHeading | pubmed-meshheading:1678132-... | lld:pubmed |
| pubmed-article:1678132 | pubmed:meshHeading | pubmed-meshheading:1678132-... | lld:pubmed |
| pubmed-article:1678132 | pubmed:meshHeading | pubmed-meshheading:1678132-... | lld:pubmed |
| pubmed-article:1678132 | pubmed:meshHeading | pubmed-meshheading:1678132-... | lld:pubmed |
| pubmed-article:1678132 | pubmed:meshHeading | pubmed-meshheading:1678132-... | lld:pubmed |
| pubmed-article:1678132 | pubmed:meshHeading | pubmed-meshheading:1678132-... | lld:pubmed |
| pubmed-article:1678132 | pubmed:meshHeading | pubmed-meshheading:1678132-... | lld:pubmed |
| pubmed-article:1678132 | pubmed:meshHeading | pubmed-meshheading:1678132-... | lld:pubmed |
| pubmed-article:1678132 | pubmed:meshHeading | pubmed-meshheading:1678132-... | lld:pubmed |
| pubmed-article:1678132 | pubmed:meshHeading | pubmed-meshheading:1678132-... | lld:pubmed |
| pubmed-article:1678132 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1678132 | pubmed:articleTitle | Effects of chronic alpha 2-adrenoceptor blockade on platelet and lymphocyte adrenoceptor binding in normal volunteers. | lld:pubmed |
| pubmed-article:1678132 | pubmed:affiliation | Reckitt and Colman Psychopharmacology Unit, School of Medical Sciences, Bristol, UK. | lld:pubmed |
| pubmed-article:1678132 | pubmed:publicationType | Journal Article | lld:pubmed |
