| pubmed-article:16780951 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16780951 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:16780951 | lifeskim:mentions | umls-concept:C1622501 | lld:lifeskim |
| pubmed-article:16780951 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:16780951 | lifeskim:mentions | umls-concept:C0165519 | lld:lifeskim |
| pubmed-article:16780951 | lifeskim:mentions | umls-concept:C0001884 | lld:lifeskim |
| pubmed-article:16780951 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:16780951 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:16780951 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16780951 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:16780951 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:16780951 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:16780951 | lifeskim:mentions | umls-concept:C1709843 | lld:lifeskim |
| pubmed-article:16780951 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16780951 | pubmed:dateCreated | 2006-9-26 | lld:pubmed |
| pubmed-article:16780951 | pubmed:abstractText | Matrix metalloproteinase-9 (MMP-9) is a secreted type IV collagenase that plays an important role in the remodeling of the extracellular matrix (ECM) and the migration of normal and tumor cells. We have shown that CpG-ODN-induced migration of RAW 264.7 cell is regulated by MMP-9 activity by using tissue inhibitors of MMP-1 (TIMP-1). The MMP-9 gene expression was transcriptionally induced by CpG-ODN in a time-dependent manner. An MMP-9 promoter-reporter was activated by the stimulation of CpG-ODN and ectopical expression of NF-kappaB transcription factor. Inhibition of NF-kappaB nuclear localization by co-expression of a mutant IkappaBalpha protein blocked the CpG-ODN-induced MMP-9 promoter activation. BMS-345541, an IKK-2 inhibitor also inhibited the expression of MMP-9 gene induced by CpG-ODN. Direct binding of NF-kappaB protein to the promoter region of the MMP-9 was confirmed by chromatin immunoprecipitation using NF-kappaB antibody. These results lead us to a conclusion that NF-kappaB activation is required for MMP-9 gene expression. In summary, our data suggest that NF-kappaB-dependent expression of MMP-9 in response to CpG-ODN plays an important role in the recruitment of immune cells. | lld:pubmed |
| pubmed-article:16780951 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16780951 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16780951 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16780951 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16780951 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16780951 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16780951 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16780951 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16780951 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16780951 | pubmed:issn | 0161-5890 | lld:pubmed |
| pubmed-article:16780951 | pubmed:author | pubmed-author:KimDoo-SikDS | lld:pubmed |
| pubmed-article:16780951 | pubmed:author | pubmed-author:LeeYoungheeY | lld:pubmed |
| pubmed-article:16780951 | pubmed:author | pubmed-author:KwonHyung-Joo... | lld:pubmed |
| pubmed-article:16780951 | pubmed:author | pubmed-author:JeonOk-HeeOH | lld:pubmed |
| pubmed-article:16780951 | pubmed:author | pubmed-author:LeeKeun-WookK... | lld:pubmed |
| pubmed-article:16780951 | pubmed:author | pubmed-author:SohnWern-JooW... | lld:pubmed |
| pubmed-article:16780951 | pubmed:author | pubmed-author:RheeJae WonJW | lld:pubmed |
| pubmed-article:16780951 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16780951 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:16780951 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16780951 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16780951 | pubmed:pagination | 1393-400 | lld:pubmed |
| pubmed-article:16780951 | pubmed:meshHeading | pubmed-meshheading:16780951... | lld:pubmed |
| pubmed-article:16780951 | pubmed:meshHeading | pubmed-meshheading:16780951... | lld:pubmed |
| pubmed-article:16780951 | pubmed:meshHeading | pubmed-meshheading:16780951... | lld:pubmed |
| pubmed-article:16780951 | pubmed:meshHeading | pubmed-meshheading:16780951... | lld:pubmed |
| pubmed-article:16780951 | pubmed:meshHeading | pubmed-meshheading:16780951... | lld:pubmed |
| pubmed-article:16780951 | pubmed:meshHeading | pubmed-meshheading:16780951... | lld:pubmed |
| pubmed-article:16780951 | pubmed:meshHeading | pubmed-meshheading:16780951... | lld:pubmed |
| pubmed-article:16780951 | pubmed:meshHeading | pubmed-meshheading:16780951... | lld:pubmed |
| pubmed-article:16780951 | pubmed:meshHeading | pubmed-meshheading:16780951... | lld:pubmed |
| pubmed-article:16780951 | pubmed:meshHeading | pubmed-meshheading:16780951... | lld:pubmed |
| pubmed-article:16780951 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:16780951 | pubmed:articleTitle | Regulation of matrix metalloproteinase-9 gene expression and cell migration by NF-kappa B in response to CpG-oligodeoxynucleotides in RAW 264.7 cells. | lld:pubmed |
| pubmed-article:16780951 | pubmed:affiliation | Department of Biochemistry and Institute of Life Science and Biotechnology, College of Science, Yonsei University, Seoul 120-749, Republic of Korea. | lld:pubmed |
| pubmed-article:16780951 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16780951 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:17395 | entrezgene:pubmed | pubmed-article:16780951 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16780951 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16780951 | lld:pubmed |
