| pubmed-article:16778987 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16778987 | lifeskim:mentions | umls-concept:C0014653 | lld:lifeskim |
| pubmed-article:16778987 | lifeskim:mentions | umls-concept:C0021083 | lld:lifeskim |
| pubmed-article:16778987 | lifeskim:mentions | umls-concept:C0079460 | lld:lifeskim |
| pubmed-article:16778987 | lifeskim:mentions | umls-concept:C0039198 | lld:lifeskim |
| pubmed-article:16778987 | lifeskim:mentions | umls-concept:C1332802 | lld:lifeskim |
| pubmed-article:16778987 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:16778987 | lifeskim:mentions | umls-concept:C1517565 | lld:lifeskim |
| pubmed-article:16778987 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:16778987 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:16778987 | pubmed:dateCreated | 2006-7-6 | lld:pubmed |
| pubmed-article:16778987 | pubmed:abstractText | CTL-associated antigen 4 (CTLA4) blockade releases inhibitory controls on T cell activation and proliferation, inducing antitumor immunity in both preclinical and early clinical trials. We examined the mechanisms of action of anti-CTLA4 and a GM-CSF-transduced tumor cell vaccine (Gvax) and their impact on the balance of effector T cells (Teffs) and Tregs in an in vivo model of B16/BL6 melanoma. Tumor challenge increased the frequency of Tregs in lymph nodes, and untreated tumors became infiltrated by CD4+Foxp3- and CD4+Foxp3+ T cells but few CD8+ T cells. Anti-CTLA4 did not deplete Tregs or permanently impair their function but acted in a cell-intrinsic manner on both Tregs and Teffs, allowing them to expand, most likely in response to self antigen. While Gvax primed the tumor-reactive Teff compartment, inducing activation, tumor infiltration, and a delay in tumor growth, the combination with CTLA4 blockade induced greater infiltration and a striking change in the intratumor balance of Tregs and Teffs that directly correlated with tumor rejection. The data suggest that Tregs control both CD4+ and CD8+ T cell activity within the tumor, highlight the importance of the intratumor ratio of effectors to regulators, and demonstrate inversion of the ratio and correlation with tumor rejection during Gvax/anti-CTLA4 immunotherapy. | lld:pubmed |
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| pubmed-article:16778987 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16778987 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16778987 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:16778987 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16778987 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:16778987 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:16778987 | pubmed:author | pubmed-author:AllisonJames... | lld:pubmed |
| pubmed-article:16778987 | pubmed:author | pubmed-author:CurranMichael... | lld:pubmed |
| pubmed-article:16778987 | pubmed:author | pubmed-author:PeggsKarl SKS | lld:pubmed |
| pubmed-article:16778987 | pubmed:author | pubmed-author:QuezadaSergio... | lld:pubmed |
| pubmed-article:16778987 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16778987 | pubmed:volume | 116 | lld:pubmed |
| pubmed-article:16778987 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16778987 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16778987 | pubmed:pagination | 1935-45 | lld:pubmed |
| pubmed-article:16778987 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:16778987 | pubmed:year | 2006 | lld:pubmed |
