| pubmed-article:16778211 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16778211 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:16778211 | lifeskim:mentions | umls-concept:C0020517 | lld:lifeskim |
| pubmed-article:16778211 | lifeskim:mentions | umls-concept:C0035339 | lld:lifeskim |
| pubmed-article:16778211 | lifeskim:mentions | umls-concept:C1326205 | lld:lifeskim |
| pubmed-article:16778211 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:16778211 | lifeskim:mentions | umls-concept:C0040845 | lld:lifeskim |
| pubmed-article:16778211 | lifeskim:mentions | umls-concept:C0206142 | lld:lifeskim |
| pubmed-article:16778211 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:16778211 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:16778211 | pubmed:dateCreated | 2006-6-16 | lld:pubmed |
| pubmed-article:16778211 | pubmed:abstractText | Hypereosinophilic syndrome (HES) has recently been recognized as a clonal leukemic lesion, which is due to a specific oncogenic event that generates hyperactive platelet-derived growth factor receptor-alpha-derived tyrosine kinase fusion proteins. In the present work, the effect of retinoids on the leukemic hypereosinophilia-derived EoL-1 cell line and on primary HES-derived cells has been investigated. We show that all-trans-retinoic acid (ATRA) inhibits eosinophil colony formation of HES-derived bone marrow cells and is a powerful inducer of apoptosis of the EoL-1 cell line. Apoptosis was shown in the nanomolar concentration range by phosphatidylserine externalization, proapoptotic shift of the Bcl-2/Bak ratio, drop in mitochondrial membrane potential, activation of caspases, and cellular morphology. Unlike in other ATRA-sensitive myeloid leukemia models, apoptosis was rapid and was not preceded by terminal cell differentiation. Use of isoform-selective synthetic retinoids indicated that retinoic acid receptor-alpha-dependent signaling is sufficient to induce apoptosis of EoL-1 cells. Our work shows that the scope of ATRA-induced apoptosis of malignancies may be wider within the myeloid lineage than thought previously, that the EoL-1 cell line constitutes a new and unique model for the study of ATRA-induced cell death, and that ATRA may have potential for the management of clonal HES. | lld:pubmed |
| pubmed-article:16778211 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16778211 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16778211 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16778211 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16778211 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16778211 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16778211 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16778211 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16778211 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16778211 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16778211 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:16778211 | pubmed:author | pubmed-author:ChomienneChri... | lld:pubmed |
| pubmed-article:16778211 | pubmed:author | pubmed-author:PappBélaB | lld:pubmed |
| pubmed-article:16778211 | pubmed:author | pubmed-author:BalitrandNico... | lld:pubmed |
| pubmed-article:16778211 | pubmed:author | pubmed-author:DelvaLaurentL | lld:pubmed |
| pubmed-article:16778211 | pubmed:author | pubmed-author:NahajevszkySa... | lld:pubmed |
| pubmed-article:16778211 | pubmed:author | pubmed-author:RobertCarineC | lld:pubmed |
| pubmed-article:16778211 | pubmed:author | pubmed-author:MassziTamàsT | lld:pubmed |
| pubmed-article:16778211 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16778211 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16778211 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:16778211 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16778211 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16778211 | pubmed:pagination | 6336-44 | lld:pubmed |
| pubmed-article:16778211 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16778211 | pubmed:meshHeading | pubmed-meshheading:16778211... | lld:pubmed |
| pubmed-article:16778211 | pubmed:meshHeading | pubmed-meshheading:16778211... | lld:pubmed |
| pubmed-article:16778211 | pubmed:meshHeading | pubmed-meshheading:16778211... | lld:pubmed |
| pubmed-article:16778211 | pubmed:meshHeading | pubmed-meshheading:16778211... | lld:pubmed |
| pubmed-article:16778211 | pubmed:meshHeading | pubmed-meshheading:16778211... | lld:pubmed |
| pubmed-article:16778211 | pubmed:meshHeading | pubmed-meshheading:16778211... | lld:pubmed |
| pubmed-article:16778211 | pubmed:meshHeading | pubmed-meshheading:16778211... | lld:pubmed |
| pubmed-article:16778211 | pubmed:meshHeading | pubmed-meshheading:16778211... | lld:pubmed |
| pubmed-article:16778211 | pubmed:meshHeading | pubmed-meshheading:16778211... | lld:pubmed |
| pubmed-article:16778211 | pubmed:meshHeading | pubmed-meshheading:16778211... | lld:pubmed |
| pubmed-article:16778211 | pubmed:meshHeading | pubmed-meshheading:16778211... | lld:pubmed |
| pubmed-article:16778211 | pubmed:meshHeading | pubmed-meshheading:16778211... | lld:pubmed |
| pubmed-article:16778211 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16778211 | pubmed:articleTitle | Apoptosis induction by retinoids in eosinophilic leukemia cells: implication of retinoic acid receptor-alpha signaling in all-trans-retinoic acid hypersensitivity. | lld:pubmed |
| pubmed-article:16778211 | pubmed:affiliation | Institut National de la Santé et de la Recherche Médicale, UMR-S 718, Institut Universitaire d'Hématologie, University of Paris VII, Paris, France. | lld:pubmed |
| pubmed-article:16778211 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16778211 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16778211 | lld:pubmed |
