Linked Life Data

16775487

Source:http://linkedlifedata.com/resource/pubmed/id/16775487

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:16775487rdf:typepubmed:Citationlld:pubmed
pubmed-article:16775487lifeskim:mentionsumls-concept:C0007634lld:lifeskim
pubmed-article:16775487lifeskim:mentionsumls-concept:C0009319lld:lifeskim
pubmed-article:16775487lifeskim:mentionsumls-concept:C1512658lld:lifeskim
pubmed-article:16775487lifeskim:mentionsumls-concept:C0021853lld:lifeskim
pubmed-article:16775487lifeskim:mentionsumls-concept:C0039194lld:lifeskim
pubmed-article:16775487lifeskim:mentionsumls-concept:C0205307lld:lifeskim
pubmed-article:16775487lifeskim:mentionsumls-concept:C1332714lld:lifeskim
pubmed-article:16775487lifeskim:mentionsumls-concept:C1704410lld:lifeskim
pubmed-article:16775487lifeskim:mentionsumls-concept:C1334114lld:lifeskim
pubmed-article:16775487lifeskim:mentionsumls-concept:C1509144lld:lifeskim
pubmed-article:16775487lifeskim:mentionsumls-concept:C0181586lld:lifeskim
pubmed-article:16775487lifeskim:mentionsumls-concept:C0205191lld:lifeskim
pubmed-article:16775487lifeskim:mentionsumls-concept:C1292733lld:lifeskim
pubmed-article:16775487lifeskim:mentionsumls-concept:C0333668lld:lifeskim
pubmed-article:16775487lifeskim:mentionsumls-concept:C0337051lld:lifeskim
pubmed-article:16775487pubmed:issue6lld:pubmed
pubmed-article:16775487pubmed:dateCreated2006-6-15lld:pubmed
pubmed-article:16775487pubmed:abstractTextBACKGROUND: CD4+CD25+ regulatory T cells have been shown to prevent immune-mediated colitis in mice; however, it is unclear whether the absence of CD4+CD25+ in the normal CD4+ T cell pool is responsible for the development of chronic colitis. Using the T cell-deficient Tgepsilon26 mouse model, we show that CD4+CD25- cells but not CD4+CD25+ cells induce a severe intestinal inflammation. Transfer of CD4+CD25+ cells, together with CD4+CD25- cells, ameliorated intestinal inflammation, and reconstitution with the whole mesenteric lymph node cell pool did not induce colitis in recipients. Transferred CD4+CD25- cells were found mainly in the mesenteric lymph nodes, where they showed an activated TH1-like phenotype. In the absence of regulatory CD4+CD25+ T cells, recipient CD4 cells secreted IFN-gamma in response to stimulation with intestinal bacterial antigen that was prevented in vivo and in vitro by regulatory CD4+CD25+ cells. These studies suggest that CD4+CD25- cells have a strong colitogenic effect in the Tgepsilon26 colitis model and that CD4+CD25+ cells may be the main regulators that prevent or downregulate the proinflammatory effect of colitogenic T cells in the Tgepsilon26 mouse model.lld:pubmed
pubmed-article:16775487pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16775487pubmed:languageenglld:pubmed
pubmed-article:16775487pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16775487pubmed:citationSubsetIMlld:pubmed
pubmed-article:16775487pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16775487pubmed:statusMEDLINElld:pubmed
pubmed-article:16775487pubmed:monthJunlld:pubmed
pubmed-article:16775487pubmed:issn1078-0998lld:pubmed
pubmed-article:16775487pubmed:authorpubmed-author:AutschbachFra...lld:pubmed
pubmed-article:16775487pubmed:authorpubmed-author:VeltkampClaud...lld:pubmed
pubmed-article:16775487pubmed:authorpubmed-author:SartorR...lld:pubmed
pubmed-article:16775487pubmed:authorpubmed-author:StremmelWolfg...lld:pubmed
pubmed-article:16775487pubmed:authorpubmed-author:VeltkampRolan...lld:pubmed
pubmed-article:16775487pubmed:authorpubmed-author:RuhwaldRebecc...lld:pubmed
pubmed-article:16775487pubmed:authorpubmed-author:GiesemThomasTlld:pubmed
pubmed-article:16775487pubmed:authorpubmed-author:KadenInesIlld:pubmed
pubmed-article:16775487pubmed:issnTypePrintlld:pubmed
pubmed-article:16775487pubmed:volume12lld:pubmed
pubmed-article:16775487pubmed:ownerNLMlld:pubmed
pubmed-article:16775487pubmed:authorsCompleteYlld:pubmed
pubmed-article:16775487pubmed:pagination437-46lld:pubmed
pubmed-article:16775487pubmed:dateRevised2007-11-14lld:pubmed
pubmed-article:16775487pubmed:meshHeadingpubmed-meshheading:16775487...lld:pubmed
pubmed-article:16775487pubmed:meshHeadingpubmed-meshheading:16775487...lld:pubmed
pubmed-article:16775487pubmed:meshHeadingpubmed-meshheading:16775487...lld:pubmed
pubmed-article:16775487pubmed:meshHeadingpubmed-meshheading:16775487...lld:pubmed
pubmed-article:16775487pubmed:meshHeadingpubmed-meshheading:16775487...lld:pubmed
pubmed-article:16775487pubmed:meshHeadingpubmed-meshheading:16775487...lld:pubmed
pubmed-article:16775487pubmed:meshHeadingpubmed-meshheading:16775487...lld:pubmed
pubmed-article:16775487pubmed:meshHeadingpubmed-meshheading:16775487...lld:pubmed
pubmed-article:16775487pubmed:meshHeadingpubmed-meshheading:16775487...lld:pubmed
pubmed-article:16775487pubmed:meshHeadingpubmed-meshheading:16775487...lld:pubmed
pubmed-article:16775487pubmed:meshHeadingpubmed-meshheading:16775487...lld:pubmed
pubmed-article:16775487pubmed:meshHeadingpubmed-meshheading:16775487...lld:pubmed
pubmed-article:16775487pubmed:meshHeadingpubmed-meshheading:16775487...lld:pubmed
pubmed-article:16775487pubmed:meshHeadingpubmed-meshheading:16775487...lld:pubmed
pubmed-article:16775487pubmed:meshHeadingpubmed-meshheading:16775487...lld:pubmed
pubmed-article:16775487pubmed:year2006lld:pubmed
pubmed-article:16775487pubmed:articleTitleCD4+CD25+ cell depletion from the normal CD4+ T cell pool prevents tolerance toward the intestinal flora and leads to chronic colitis in immunodeficient mice.lld:pubmed
pubmed-article:16775487pubmed:affiliationDepartment of Gastroenterology, Ruprecht-Karls-University, Heidelberg, Germany. Claudia_veltkamp@med.uni-heidelberg.delld:pubmed
pubmed-article:16775487pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16775487pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:16775487pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16775487lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16775487lld:pubmed