| pubmed-article:16775347 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16775347 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:16775347 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:16775347 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:16775347 | lifeskim:mentions | umls-concept:C1160185 | lld:lifeskim |
| pubmed-article:16775347 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:16775347 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:16775347 | pubmed:dateCreated | 2006-6-15 | lld:pubmed |
| pubmed-article:16775347 | pubmed:abstractText | Tumor cells and vasculature offer specific targets for the selective delivery of therapeutic genes. To achieve tumor-specific gene transfer, baculovirus tropism was manipulated by viral envelope modification using baculovirus display technology. LyP-1, F3, and CGKRK tumor-homing peptides, originally identified by in vivo screening of phage display libraries, were fused to the transmembrane anchor of vesicular stomatitis virus G protein and displayed on the baculoviral surface. The fusion proteins were successfully incorporated into budded virions, which showed two- to fivefold-improved binding to human breast carcinoma (MDA-MB-435) and hepatocarcinoma (HepG2) cells. The LyP-1 peptide inhibited viral binding to MDA-MB-435 cells with a greater magnitude and specificity than the CGKRK and F3 peptides. Maximal 7- and 24-fold increases in transduction, determined by transgene expression level, were achieved for the MDA-MB-435 and HepG2 cells, respectively. The internalization of each virus was inhibited by ammonium chloride treatment, suggesting the use of a similar endocytic entry route. The LyP-1 and F3 peptides showed an apparent inhibitory effect in transduction of HepG2 cells with the corresponding display viruses. Together, these results imply that the efficiency of baculovirus-mediated gene delivery can be significantly enhanced in vitro when tumor-targeting ligands are used and therefore highlight the potential of baculovirus vectors in cancer gene therapy. | lld:pubmed |
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| pubmed-article:16775347 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16775347 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16775347 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16775347 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:16775347 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:16775347 | pubmed:author | pubmed-author:RuoslahtiErkk... | lld:pubmed |
| pubmed-article:16775347 | pubmed:author | pubmed-author:WhiteDaniel... | lld:pubmed |
| pubmed-article:16775347 | pubmed:author | pubmed-author:MatilainenHel... | lld:pubmed |
| pubmed-article:16775347 | pubmed:author | pubmed-author:Oker-BlomChri... | lld:pubmed |
| pubmed-article:16775347 | pubmed:author | pubmed-author:MäkeläAnna... | lld:pubmed |
| pubmed-article:16775347 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16775347 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:16775347 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16775347 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16775347 | pubmed:pagination | 6603-11 | lld:pubmed |
| pubmed-article:16775347 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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