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pubmed-article:16768788pubmed:abstractTextRecent developments in DNA microarray technology led to a variety of open and closed devices and systems including high and low density microarrays for high-throughput screening applications as well as microarrays of lower density for specific diagnostic purposes. Beside predefined microarrays for specific applications manufacturers offer the production of custom-designed microarrays adapted to customers' wishes. Array based assays demand complex procedures including several steps for sample preparation (RNA extraction, amplification and sample labelling), hybridization and detection, thus leading to a high variability between several approaches and resulting in the necessity of extensive standardization and normalization procedures.lld:pubmed
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pubmed-article:16768788pubmed:articleTitleAn alternative method to amplify RNA without loss of signal conservation for expression analysis with a proteinase DNA microarray in the ArrayTube format.lld:pubmed
pubmed-article:16768788pubmed:affiliationInstitute of Biochemistry, Klinikum, Friedrich-Schiller-Universität Jena, Germany. susch@mti.uni-jena.delld:pubmed
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