| pubmed-article:1676007 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1676007 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:1676007 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:1676007 | lifeskim:mentions | umls-concept:C0011812 | lld:lifeskim |
| pubmed-article:1676007 | lifeskim:mentions | umls-concept:C0040615 | lld:lifeskim |
| pubmed-article:1676007 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1676007 | lifeskim:mentions | umls-concept:C0070559 | lld:lifeskim |
| pubmed-article:1676007 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1676007 | pubmed:dateCreated | 1991-7-31 | lld:pubmed |
| pubmed-article:1676007 | pubmed:abstractText | 1. Mouse striatal 2-phenylethylamine was not changed at 2 hr following the administration of chlorpromazine, fluphenazine or spiperone. 2. In contrast, when the mice were first given pargyline (2 mg kg-1), treated with chlorpromazine, fluphenazine or spiperone 2 hr later and killed at 4 hr, a significant increase (to 130-170%) in the accumulation of 2-phenylethylamine was observed with respect to the pargyline controls. 3. The effect of chlorpromazine was consistently observed after pretreatment with either deprenyl (2 mg kg -1) or high doses (200 mg kg-1) of pargyline that produced different degrees of MAO inhibition. 4. Following pretreatment with pargyline (2 mg kg-1), d-amphetamine (5 mg kg-1) produced a significant reduction in striatal 2-phenylethylamine concentrations (to 39% of pargyline-treated controls). 5. The findings show that inhibition of dopamine transmission by neuroleptics increases the rate of 2-phenylethylamine accumulation. 6. Conversely, a stimulation of dopamine transmission by d-amphetamine results in a reduction in the rate of accumulation of 2-phenylethylamine and supports the concept of 2-phenylethylamine may be a neuromodulator of dopamine transmission. | lld:pubmed |
| pubmed-article:1676007 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1676007 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1676007 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1676007 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1676007 | pubmed:issn | 0306-3623 | lld:pubmed |
| pubmed-article:1676007 | pubmed:author | pubmed-author:LeeY TYT | lld:pubmed |
| pubmed-article:1676007 | pubmed:author | pubmed-author:JuorioA VAV | lld:pubmed |
| pubmed-article:1676007 | pubmed:author | pubmed-author:GreenshawA... | lld:pubmed |
| pubmed-article:1676007 | pubmed:author | pubmed-author:PatersonI AIA | lld:pubmed |
| pubmed-article:1676007 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1676007 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:1676007 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1676007 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1676007 | pubmed:pagination | 407-13 | lld:pubmed |
| pubmed-article:1676007 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1676007 | pubmed:meshHeading | pubmed-meshheading:1676007-... | lld:pubmed |
| pubmed-article:1676007 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1676007 | pubmed:articleTitle | The effects of some neuroleptics and d-amphetamine on striatal 2-phenylethylamine in the mouse. | lld:pubmed |
| pubmed-article:1676007 | pubmed:affiliation | Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada. | lld:pubmed |
| pubmed-article:1676007 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1676007 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1676007 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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