| pubmed-article:1675832 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1675832 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:1675832 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:1675832 | lifeskim:mentions | umls-concept:C0004112 | lld:lifeskim |
| pubmed-article:1675832 | lifeskim:mentions | umls-concept:C0019588 | lld:lifeskim |
| pubmed-article:1675832 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:1675832 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:1675832 | pubmed:dateCreated | 1991-7-24 | lld:pubmed |
| pubmed-article:1675832 | pubmed:abstractText | The characteristics of histamine H1-receptors expressed on astrocytes from the cerebral cortex of new born rats were analysed by the [3H]-mepyramine binding assay. The apparent dissociation constant (Kd) was 10.4 nM and the binding capacity (Bmax) of 262 fmol/mg protein. H1-antagonists inhibited the [3H]mepyramine bindings and the isomers of chlorpheniramine showed a stereoselectivity for the inhibition of the bindings. Two distinct populations of cultured astrocytes, type-1 and type-2 astrocytes, were enriched and histamine-induced accumulations of inositol phosphates (IP) and cyclic AMP and histamine-evoked Ca++ signals were examined. Histamine stimulated the accumulation of IP in type-2 astrocytes, but not in type-1 astrocytes. The accumulation of cyclic AMP induced by histamine was observed in type-1 astrocytes, although not in type-2 astrocytes. Histamine-induced Ca++ signals were observed in 17.2% of type-1 astrocytes and in 72.9% of type-2 astrocytes. Histamine-induced Ca++ signals in type-2 astrocytes were antagonized by H1-antagonists, but not by H2- antagonists. Histamine-induced Ca++ signals were classified into 4 patterns, ie. transient, oscillatory, sustained and biphasic. When extracellular Ca++ was omitted or La was added to the extracellular medium, sustained phase of Ca++ signal disappeared and transient and oscillatory patterns were only observed. Phorbol ester inhibited histamine-induced Ca++ signals but pertussis toxin (IAP) and organic voltage dependent Ca++ channel blockers had no effect. Histamine-induced Ca++ elevation appeared initially in processes and then Ca++ wave propagated to the cell soma. Ca++ elevation was observed only in the processes in some cells. | lld:pubmed |
| pubmed-article:1675832 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1675832 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1675832 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1675832 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1675832 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1675832 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1675832 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1675832 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1675832 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1675832 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1675832 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1675832 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1675832 | pubmed:issn | 0379-0363 | lld:pubmed |
| pubmed-article:1675832 | pubmed:author | pubmed-author:ItoSS | lld:pubmed |
| pubmed-article:1675832 | pubmed:author | pubmed-author:FukuiHH | lld:pubmed |
| pubmed-article:1675832 | pubmed:author | pubmed-author:KuboAA | lld:pubmed |
| pubmed-article:1675832 | pubmed:author | pubmed-author:WadaHH | lld:pubmed |
| pubmed-article:1675832 | pubmed:author | pubmed-author:YamatodaniAA | lld:pubmed |
| pubmed-article:1675832 | pubmed:author | pubmed-author:KondohHH | lld:pubmed |
| pubmed-article:1675832 | pubmed:author | pubmed-author:InagakiNN | lld:pubmed |
| pubmed-article:1675832 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1675832 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:1675832 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1675832 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1675832 | pubmed:pagination | 161-80 | lld:pubmed |
| pubmed-article:1675832 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1675832 | pubmed:meshHeading | pubmed-meshheading:1675832-... | lld:pubmed |
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| pubmed-article:1675832 | pubmed:meshHeading | pubmed-meshheading:1675832-... | lld:pubmed |
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| pubmed-article:1675832 | pubmed:meshHeading | pubmed-meshheading:1675832-... | lld:pubmed |
| pubmed-article:1675832 | pubmed:meshHeading | pubmed-meshheading:1675832-... | lld:pubmed |
| pubmed-article:1675832 | pubmed:meshHeading | pubmed-meshheading:1675832-... | lld:pubmed |
| pubmed-article:1675832 | pubmed:meshHeading | pubmed-meshheading:1675832-... | lld:pubmed |
| pubmed-article:1675832 | pubmed:meshHeading | pubmed-meshheading:1675832-... | lld:pubmed |
| pubmed-article:1675832 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1675832 | pubmed:articleTitle | Histamine H1-receptors on astrocytes in primary cultures: a possible target for histaminergic neurones. | lld:pubmed |
| pubmed-article:1675832 | pubmed:affiliation | Department of Pharmacology II, Faculty of Medicine, Osaka University, Japan. | lld:pubmed |
| pubmed-article:1675832 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1675832 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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