| pubmed-article:16756961 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16756961 | lifeskim:mentions | umls-concept:C0332437 | lld:lifeskim |
| pubmed-article:16756961 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:16756961 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16756961 | lifeskim:mentions | umls-concept:C0596632 | lld:lifeskim |
| pubmed-article:16756961 | lifeskim:mentions | umls-concept:C0082584 | lld:lifeskim |
| pubmed-article:16756961 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:16756961 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:16756961 | lifeskim:mentions | umls-concept:C1512488 | lld:lifeskim |
| pubmed-article:16756961 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16756961 | pubmed:dateCreated | 2006-6-19 | lld:pubmed |
| pubmed-article:16756961 | pubmed:abstractText | FK506-binding proteins are the peptidyl prolyl cis-trans isomerases that are involved in various intracellular events. We characterized a novel mouse FK506-binding protein homolog, FKBP133/KIAA0674, in the developing nervous system. FKBP133 contains a domain similar to Wiskott-Aldrich syndrome protein homology region 1 (WH1) and a domain homologous to FK506-binding protein motif. FKBP133 was predominantly expressed in cerebral cortex, hippocampus, and peripheral ganglia at embryonic day 18.5. FKBP133 protein was distributed in the axonal shafts and was partially co-localized with F-actin in the growth cones of dorsal root ganglion neurons (DRG). The number of filopodia was increased in the DRG neurons overexpressing FKBP133. In contrast, the overexpression of a mutant deleted the WH1 domain reduced the growth cone size and the number of filopodia. Furthermore, the neurons overexpressing FKBP133 became significantly resistant to Semaphorin-3A induced collapse response. These results suggest that FKBP133 modulates growth cone behavior with the WH1 domain. | lld:pubmed |
| pubmed-article:16756961 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16756961 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16756961 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16756961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16756961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16756961 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16756961 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:16756961 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:16756961 | pubmed:author | pubmed-author:GoshimaYoshio... | lld:pubmed |
| pubmed-article:16756961 | pubmed:author | pubmed-author:IwamatsuAkihi... | lld:pubmed |
| pubmed-article:16756961 | pubmed:author | pubmed-author:FujisawaHajim... | lld:pubmed |
| pubmed-article:16756961 | pubmed:author | pubmed-author:SutoFumikazuF | lld:pubmed |
| pubmed-article:16756961 | pubmed:author | pubmed-author:KondoEisakuE | lld:pubmed |
| pubmed-article:16756961 | pubmed:author | pubmed-author:NakamuraFumio... | lld:pubmed |
| pubmed-article:16756961 | pubmed:author | pubmed-author:NakajimaOumiO | lld:pubmed |
| pubmed-article:16756961 | pubmed:author | pubmed-author:YamashitaNaoy... | lld:pubmed |
| pubmed-article:16756961 | pubmed:author | pubmed-author:TomitaYusukeY | lld:pubmed |
| pubmed-article:16756961 | pubmed:author | pubmed-author:TakeiKohtaroK | lld:pubmed |
| pubmed-article:16756961 | pubmed:author | pubmed-author:OkadaTakakoT | lld:pubmed |
| pubmed-article:16756961 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16756961 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:16756961 | pubmed:volume | 346 | lld:pubmed |
| pubmed-article:16756961 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16756961 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16756961 | pubmed:pagination | 140-9 | lld:pubmed |
| pubmed-article:16756961 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16756961 | pubmed:meshHeading | pubmed-meshheading:16756961... | lld:pubmed |
| pubmed-article:16756961 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16756961 | pubmed:articleTitle | FKBP133: a novel mouse FK506-binding protein homolog alters growth cone morphology. | lld:pubmed |
| pubmed-article:16756961 | pubmed:affiliation | Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan. | lld:pubmed |
| pubmed-article:16756961 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16756961 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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