| pubmed-article:16754959 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16754959 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:16754959 | lifeskim:mentions | umls-concept:C1383501 | lld:lifeskim |
| pubmed-article:16754959 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:16754959 | lifeskim:mentions | umls-concept:C0021549 | lld:lifeskim |
| pubmed-article:16754959 | lifeskim:mentions | umls-concept:C0600430 | lld:lifeskim |
| pubmed-article:16754959 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:16754959 | pubmed:dateCreated | 2006-6-6 | lld:pubmed |
| pubmed-article:16754959 | pubmed:abstractText | We developed genetically encoded fluorescent inositol 1,4,5-trisphosphate (IP3) sensors that do not severely interfere with intracellular Ca2+ dynamics and used them to monitor the spatiotemporal dynamics of both cytosolic IP3 and Ca2+ in single HeLa cells after stimulation of exogenously expressed metabotropic glutamate receptor 5a or endogenous histamine receptors. IP3 started to increase at a relatively constant rate before the pacemaker Ca2+ rise, and the subsequent abrupt Ca2+ rise was not accompanied by any acceleration in the rate of increase in IP3. Cytosolic [IP3] did not return to its basal level during the intervals between Ca2+ spikes, and IP3 gradually accumulated in the cytosol with a little or no fluctuations during cytosolic Ca2+ oscillations. These results indicate that the Ca2+ -induced regenerative IP3 production is not a driving force of the upstroke of Ca2+ spikes and that the apparent IP3 sensitivity for Ca2+ spike generation progressively decreases during Ca2+ oscillations. | lld:pubmed |
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| pubmed-article:16754959 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16754959 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16754959 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16754959 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16754959 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16754959 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:16754959 | pubmed:author | pubmed-author:MikoshibaKats... | lld:pubmed |
| pubmed-article:16754959 | pubmed:author | pubmed-author:MiyawakiAtsus... | lld:pubmed |
| pubmed-article:16754959 | pubmed:author | pubmed-author:Matsu-uraToru... | lld:pubmed |
| pubmed-article:16754959 | pubmed:author | pubmed-author:YoshidaManabu... | lld:pubmed |
| pubmed-article:16754959 | pubmed:author | pubmed-author:MichikawaTaka... | lld:pubmed |
| pubmed-article:16754959 | pubmed:author | pubmed-author:InoueTakafumi... | lld:pubmed |
| pubmed-article:16754959 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16754959 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:16754959 | pubmed:volume | 173 | lld:pubmed |
| pubmed-article:16754959 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16754959 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16754959 | pubmed:pagination | 755-65 | lld:pubmed |
| pubmed-article:16754959 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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