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pubmed-article:16753872pubmed:dateCreated2006-6-6lld:pubmed
pubmed-article:16753872pubmed:abstractTextTo our knowledge, there has been no report of spontaneous regression in a non-immunocompromised adult with classical Hodgkin's lymphoma (HL) in the absence of chemotherapy. We describe spontaneous regression and subsequent relapse of Epstein - Barr virus (EBV)-positive HL in an otherwise healthy male adult. The clinical course was associated with an increase in regulatory T-cell markers within the peripheral blood and diseased lymph node at the time of relapse and with a concomitant reduction in cellular immunity against relevant EBV latent membrane protein tumor-associated antigens. Our findings are in keeping with previous observations that implicate impaired cellular immunity in the immunopathogenesis of EBV-positive HL.lld:pubmed
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pubmed-article:16753872pubmed:authorpubmed-author:WilsonW MWMlld:pubmed
pubmed-article:16753872pubmed:authorpubmed-author:GriggA PAPlld:pubmed
pubmed-article:16753872pubmed:authorpubmed-author:GandhiM KMKlld:pubmed
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pubmed-article:16753872pubmed:year2006lld:pubmed
pubmed-article:16753872pubmed:articleTitleCorrelation of T-cell immune response with spontaneous resolution and subsequent relapse of Hodgkin's lymphoma.lld:pubmed
pubmed-article:16753872pubmed:affiliationDepartment of Clinical Haematology, Royal Melbourne Hospital, Parkville, Victoria, Australia.lld:pubmed
pubmed-article:16753872pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16753872pubmed:publicationTypeCase Reportslld:pubmed