Linked Life Data

16751793

Source:http://linkedlifedata.com/resource/pubmed/id/16751793

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:16751793rdf:typepubmed:Citationlld:pubmed
pubmed-article:16751793lifeskim:mentionsumls-concept:C0000768lld:lifeskim
pubmed-article:16751793lifeskim:mentionsumls-concept:C0037380lld:lifeskim
pubmed-article:16751793lifeskim:mentionsumls-concept:C0206313lld:lifeskim
pubmed-article:16751793lifeskim:mentionsumls-concept:C0019120lld:lifeskim
pubmed-article:16751793lifeskim:mentionsumls-concept:C0061751lld:lifeskim
pubmed-article:16751793lifeskim:mentionsumls-concept:C1280500lld:lifeskim
pubmed-article:16751793lifeskim:mentionsumls-concept:C0205263lld:lifeskim
pubmed-article:16751793pubmed:issue6lld:pubmed
pubmed-article:16751793pubmed:dateCreated2006-7-17lld:pubmed
pubmed-article:16751793pubmed:abstractText1. Envenomation by the snake Bothrops jararaca is typically associated with hemostatic abnormalities including pro- and anticoagulant disturbances. Glycyrrhizin (GL) is a plant-derived thrombin inhibitor that also exhibits in vivo antithrombotic properties. Here, we evaluated the ability of GL to counteract the hemostatic abnormalities promoted by B. jararaca venom. 2. GL inhibited the human fibrinogen clotting (IC50 = approximately 1.0 mg ml(-1); 1.2 mM), H-D-phenylalanyl-L-pipecolyl-L-arginine-p-nitroanilide dihydrochloride hydrolysis (IC50 = approximately 0.4 mg ml(-1); 0.47 mM) and platelet aggregation (IC50 = approximately 0.28 mg ml(-1); 0.33 mM) induced by B. jararaca venom, in vitro. 3. The in vivo effect of GL was tested in rats using a model of venous thrombosis in which intravenous (i.v.) administration of B. jararaca venom (100 microg kg(-1)) produced in all animals a thrombus with a mean weight of 10.6+/-1.7 mg. 4. Prior administration of GL (180 mg kg(-1)) or antibothropic serum (27 microl kg(-1)) inhibited thrombus formation by 86 and 67%, respectively. Remarkably, co-administration of ineffective doses of GL and antibothropic serum markedly decreased thrombus weight, suggesting a synergistic effect. 5. Co-administration of GL with antibothropic serum abolished venom-induced bleeding. Ex vivo clotting times showed that rat plasma was non-clotting after i.v. administration of B. jararaca venom. Treatment with GL, antibothropic serum or both before venom administration efficiently prevented this abnormality. 6. Altogether, we demonstrate here that GL prevents both in vitro and in vivo venom-induced changes in hemostasis, suggesting a potential antiophidic activity.lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:languageenglld:pubmed
pubmed-article:16751793pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:citationSubsetIMlld:pubmed
pubmed-article:16751793pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16751793pubmed:statusMEDLINElld:pubmed
pubmed-article:16751793pubmed:monthJullld:pubmed
pubmed-article:16751793pubmed:issn0007-1188lld:pubmed
pubmed-article:16751793pubmed:authorpubmed-author:MonteiroRobso...lld:pubmed
pubmed-article:16751793pubmed:authorpubmed-author:ZingaliRussol...lld:pubmed
pubmed-article:16751793pubmed:authorpubmed-author:GuimarãesJorg...lld:pubmed
pubmed-article:16751793pubmed:authorpubmed-author:AssafimMarian...lld:pubmed
pubmed-article:16751793pubmed:authorpubmed-author:FerreiraMarco...lld:pubmed
pubmed-article:16751793pubmed:authorpubmed-author:FrattaniFlávi...lld:pubmed
pubmed-article:16751793pubmed:issnTypePrintlld:pubmed
pubmed-article:16751793pubmed:volume148lld:pubmed
pubmed-article:16751793pubmed:ownerNLMlld:pubmed
pubmed-article:16751793pubmed:authorsCompleteYlld:pubmed
pubmed-article:16751793pubmed:pagination807-13lld:pubmed
pubmed-article:16751793pubmed:dateRevised2009-11-18lld:pubmed
pubmed-article:16751793pubmed:meshHeadingpubmed-meshheading:16751793...lld:pubmed
pubmed-article:16751793pubmed:meshHeadingpubmed-meshheading:16751793...lld:pubmed
pubmed-article:16751793pubmed:meshHeadingpubmed-meshheading:16751793...lld:pubmed
pubmed-article:16751793pubmed:meshHeadingpubmed-meshheading:16751793...lld:pubmed
pubmed-article:16751793pubmed:meshHeadingpubmed-meshheading:16751793...lld:pubmed
pubmed-article:16751793pubmed:meshHeadingpubmed-meshheading:16751793...lld:pubmed
pubmed-article:16751793pubmed:meshHeadingpubmed-meshheading:16751793...lld:pubmed
pubmed-article:16751793pubmed:meshHeadingpubmed-meshheading:16751793...lld:pubmed
pubmed-article:16751793pubmed:meshHeadingpubmed-meshheading:16751793...lld:pubmed
pubmed-article:16751793pubmed:meshHeadingpubmed-meshheading:16751793...lld:pubmed
pubmed-article:16751793pubmed:meshHeadingpubmed-meshheading:16751793...lld:pubmed
pubmed-article:16751793pubmed:meshHeadingpubmed-meshheading:16751793...lld:pubmed
pubmed-article:16751793pubmed:meshHeadingpubmed-meshheading:16751793...lld:pubmed
pubmed-article:16751793pubmed:year2006lld:pubmed
pubmed-article:16751793pubmed:articleTitleCounteracting effect of glycyrrhizin on the hemostatic abnormalities induced by Bothrops jararaca snake venom.lld:pubmed
pubmed-article:16751793pubmed:affiliationInstituto de Bioquímica Médica, Programa de Biologia Estrutural, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.lld:pubmed
pubmed-article:16751793pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16751793pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed