| pubmed-article:16750486 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16750486 | lifeskim:mentions | umls-concept:C0206745 | lld:lifeskim |
| pubmed-article:16750486 | lifeskim:mentions | umls-concept:C1176472 | lld:lifeskim |
| pubmed-article:16750486 | lifeskim:mentions | umls-concept:C0019564 | lld:lifeskim |
| pubmed-article:16750486 | lifeskim:mentions | umls-concept:C0001041 | lld:lifeskim |
| pubmed-article:16750486 | lifeskim:mentions | umls-concept:C0036751 | lld:lifeskim |
| pubmed-article:16750486 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:16750486 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:16750486 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:16750486 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:16750486 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:16750486 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:16750486 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16750486 | pubmed:dateCreated | 2006-6-5 | lld:pubmed |
| pubmed-article:16750486 | pubmed:abstractText | Lesioning of serotonergic afferents increases hippocampal ACh release and attenuates memory deficits produced by cholinergic lesions. Improved memory performance described in 5-HT1B-knockout (KO) mice might thus be due to a weaker 5-HT1B-mediated inhibitory influence of 5-HT on hippocampal ACh release. The selective delay-dependent impairment of working memory observed in these KO mice suggests, however, that cortical regions also participate in task performance, possibly via indirect influences of 5-HT on ACh release. To provide neuropharmacological support for these hypotheses we measured evoked ACh and 5-HT release in hippocampal and cortical slices of wild-type (WT) and 5-HT1B KO mice. Superfused slices (preincubated with [3H]choline or [3H]5-HT) were electrically stimulated in the absence or presence of 5-HT1B receptor ligands. In hippocampus and cortex, 5-HT1B agonists decreased and antagonists increased 5-HT release in WT, but not in 5-HT1B KO mice. In 5-HT1B KO mice, 5-HT release was enhanced in both structures, while ACh release (in nCi) was reduced. ACh release was inhibited by 5-HT1B agonists in hippocampal (not cortical) slices of WT but not of 5-HT1B KO mice. Our data (i) confirm the absence of autoinhibition of 5-HT release in 5-HT1B-KO mice, (ii) demonstrate a reduced release of ACh, and the absence of 5-HT1B-receptor-mediated inhibition of ACh release, in the hippocampus and cortex of 5-HT1B-KO mice, and (iii) are compatible with an indirect role of cortical ACh in the working memory impairment observed in these KO mice. | lld:pubmed |
| pubmed-article:16750486 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16750486 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750486 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16750486 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750486 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750486 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750486 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750486 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750486 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750486 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750486 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750486 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750486 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750486 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750486 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16750486 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16750486 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16750486 | pubmed:issn | 0361-9230 | lld:pubmed |
| pubmed-article:16750486 | pubmed:author | pubmed-author:CasselJean-Ch... | lld:pubmed |
| pubmed-article:16750486 | pubmed:author | pubmed-author:JackischRolfR | lld:pubmed |
| pubmed-article:16750486 | pubmed:author | pubmed-author:BuhotMarie-Ch... | lld:pubmed |
| pubmed-article:16750486 | pubmed:author | pubmed-author:RiegertCéline... | lld:pubmed |
| pubmed-article:16750486 | pubmed:author | pubmed-author:RutzSusanneS | lld:pubmed |
| pubmed-article:16750486 | pubmed:author | pubmed-author:RothmaierAnna... | lld:pubmed |
| pubmed-article:16750486 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16750486 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16750486 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:16750486 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16750486 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16750486 | pubmed:pagination | 81-93 | lld:pubmed |
| pubmed-article:16750486 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:16750486 | pubmed:meshHeading | pubmed-meshheading:16750486... | lld:pubmed |
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| pubmed-article:16750486 | pubmed:meshHeading | pubmed-meshheading:16750486... | lld:pubmed |
| pubmed-article:16750486 | pubmed:meshHeading | pubmed-meshheading:16750486... | lld:pubmed |
| pubmed-article:16750486 | pubmed:meshHeading | pubmed-meshheading:16750486... | lld:pubmed |
| pubmed-article:16750486 | pubmed:meshHeading | pubmed-meshheading:16750486... | lld:pubmed |
| pubmed-article:16750486 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16750486 | pubmed:articleTitle | Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice. | lld:pubmed |
| pubmed-article:16750486 | pubmed:affiliation | Institute of Experimental and Clinical Pharmacology and Toxicology, Laboratory of Neuropharmacology, University of Freiburg, Hansastrasse 9A, D-79104 Freiburg, Germany. | lld:pubmed |
| pubmed-article:16750486 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16750486 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16750486 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:15551 | entrezgene:pubmed | pubmed-article:16750486 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16750486 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16750486 | lld:pubmed |
