| pubmed-article:16749936 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16749936 | lifeskim:mentions | umls-concept:C1882071 | lld:lifeskim |
| pubmed-article:16749936 | lifeskim:mentions | umls-concept:C0019409 | lld:lifeskim |
| pubmed-article:16749936 | lifeskim:mentions | umls-concept:C0679201 | lld:lifeskim |
| pubmed-article:16749936 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:16749936 | lifeskim:mentions | umls-concept:C0150098 | lld:lifeskim |
| pubmed-article:16749936 | lifeskim:mentions | umls-concept:C1706233 | lld:lifeskim |
| pubmed-article:16749936 | lifeskim:mentions | umls-concept:C2348867 | lld:lifeskim |
| pubmed-article:16749936 | pubmed:dateCreated | 2006-7-14 | lld:pubmed |
| pubmed-article:16749936 | pubmed:abstractText | The learning of global genetic regulatory networks from expression data is a severely under-constrained problem that is aided by reducing the dimensionality of the search space by means of clustering genes into putatively co-regulated groups, as opposed to those that are simply co-expressed. Be cause genes may be co-regulated only across a subset of all observed experimental conditions, biclustering (clustering of genes and conditions) is more appropriate than standard clustering. Co-regulated genes are also often functionally (physically, spatially, genetically, and/or evolutionarily) associated, and such a priori known or pre-computed associations can provide support for appropriately grouping genes. One important association is the presence of one or more common cis-regulatory motifs. In organisms where these motifs are not known, their de novo detection, integrated into the clustering algorithm, can help to guide the process towards more biologically parsimonious solutions. | lld:pubmed |
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| pubmed-article:16749936 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16749936 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16749936 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16749936 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16749936 | pubmed:issn | 1471-2105 | lld:pubmed |
| pubmed-article:16749936 | pubmed:author | pubmed-author:BonneauRichar... | lld:pubmed |
| pubmed-article:16749936 | pubmed:author | pubmed-author:BaligaNitin... | lld:pubmed |
| pubmed-article:16749936 | pubmed:author | pubmed-author:ReissDavid... | lld:pubmed |
| pubmed-article:16749936 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16749936 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:16749936 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16749936 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16749936 | pubmed:pagination | 280 | lld:pubmed |
| pubmed-article:16749936 | pubmed:dateRevised | 2010-9-15 | lld:pubmed |
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