| pubmed-article:1674536 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1674536 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:1674536 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1674536 | lifeskim:mentions | umls-concept:C1979844 | lld:lifeskim |
| pubmed-article:1674536 | lifeskim:mentions | umls-concept:C1514758 | lld:lifeskim |
| pubmed-article:1674536 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:1674536 | lifeskim:mentions | umls-concept:C0049322 | lld:lifeskim |
| pubmed-article:1674536 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1674536 | pubmed:dateCreated | 1991-6-24 | lld:pubmed |
| pubmed-article:1674536 | pubmed:abstractText | Our study had three purposes: 1) to determine whether 5-methyl-urapidil, topically applied to the ventrolateral medulla, produces hypotension by activating serotonin-1A (5-HT1A) receptors, 2) to determine whether 5-methyl-urapidil given i.v. produces hypotension in part by activating 5-HT1A receptors in the ventrolateral medulla, and 3) to determine the specific site within the ventrolateral medulla where 5-methyl-urapidil elicits a hypotensive response. In terms of the first purpose, 5-methyl-urapidil applied bilaterally to the intermediate area of the ventral surface of the medulla (1.2 micrograms/side) of chloralose-anesthetized cats produced a decrease in mean arterial pressure of -39 +/- 4 mm Hg (N = 8). Prior blockade of 5-HT1A receptors at this site with bilateral application of spiperone (30 micrograms/side) prevented the hypotensive effect of 5-methyl-urapidil (mean blood pressure now increased by 5 +/- 4 mm Hg). Pretreatment with the alpha-1 adrenoceptor antagonist, prazosin, did not prevent the hypotensive effect of 5-methyl-urapidil. In terms of the second purpose, spiperone applied bilaterally to the ventral surface of the medulla counteracted a significant portion of the hypotensive effect of 5-methyl-urapidil given by the i.v. route. The dose of 5-methyl-urapidil given intravenously was below the dose that produces alpha-1 adrenoceptor blockade. In terms of the third purpose, microinjection of 5-methyl-urapidil into central nervous system sites associated with the intermediate area was found to have its greatest hypotensive effect at the subretrofacial nucleus. Mean arterial pressure decreased by 74 +/- 14 mm Hg (N = 3) after bilateral microinjection of 25 ng of the drug.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:1674536 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1674536 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1674536 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1674536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1674536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1674536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1674536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1674536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1674536 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1674536 | pubmed:month | May | lld:pubmed |
| pubmed-article:1674536 | pubmed:issn | 0022-3565 | lld:pubmed |
| pubmed-article:1674536 | pubmed:author | pubmed-author:GillisR ARA | lld:pubmed |
| pubmed-article:1674536 | pubmed:author | pubmed-author:MandalA KAK | lld:pubmed |
| pubmed-article:1674536 | pubmed:author | pubmed-author:KellarK JKJ | lld:pubmed |
| pubmed-article:1674536 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1674536 | pubmed:volume | 257 | lld:pubmed |
| pubmed-article:1674536 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1674536 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1674536 | pubmed:pagination | 861-9 | lld:pubmed |
| pubmed-article:1674536 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1674536 | pubmed:meshHeading | pubmed-meshheading:1674536-... | lld:pubmed |
| pubmed-article:1674536 | pubmed:meshHeading | pubmed-meshheading:1674536-... | lld:pubmed |
| pubmed-article:1674536 | pubmed:meshHeading | pubmed-meshheading:1674536-... | lld:pubmed |
| pubmed-article:1674536 | pubmed:meshHeading | pubmed-meshheading:1674536-... | lld:pubmed |
| pubmed-article:1674536 | pubmed:meshHeading | pubmed-meshheading:1674536-... | lld:pubmed |
| pubmed-article:1674536 | pubmed:meshHeading | pubmed-meshheading:1674536-... | lld:pubmed |
| pubmed-article:1674536 | pubmed:meshHeading | pubmed-meshheading:1674536-... | lld:pubmed |
| pubmed-article:1674536 | pubmed:meshHeading | pubmed-meshheading:1674536-... | lld:pubmed |
| pubmed-article:1674536 | pubmed:meshHeading | pubmed-meshheading:1674536-... | lld:pubmed |
| pubmed-article:1674536 | pubmed:meshHeading | pubmed-meshheading:1674536-... | lld:pubmed |
| pubmed-article:1674536 | pubmed:meshHeading | pubmed-meshheading:1674536-... | lld:pubmed |
| pubmed-article:1674536 | pubmed:meshHeading | pubmed-meshheading:1674536-... | lld:pubmed |
| pubmed-article:1674536 | pubmed:meshHeading | pubmed-meshheading:1674536-... | lld:pubmed |
| pubmed-article:1674536 | pubmed:meshHeading | pubmed-meshheading:1674536-... | lld:pubmed |
| pubmed-article:1674536 | pubmed:meshHeading | pubmed-meshheading:1674536-... | lld:pubmed |
| pubmed-article:1674536 | pubmed:meshHeading | pubmed-meshheading:1674536-... | lld:pubmed |
| pubmed-article:1674536 | pubmed:meshHeading | pubmed-meshheading:1674536-... | lld:pubmed |
| pubmed-article:1674536 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1674536 | pubmed:articleTitle | The role of serotonin-1A receptor activation and alpha-1 adrenoceptor blockade in the hypotensive effect of 5-methyl-urapidil. | lld:pubmed |
| pubmed-article:1674536 | pubmed:affiliation | Department of Pharmacology, Georgetown University School of Medicine, Washington, D.C. | lld:pubmed |
| pubmed-article:1674536 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1674536 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1674536 | lld:pubmed |
