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pubmed-article:16741301pubmed:abstractTextAs part of the radioiodinated 4-amino-N-1-[3-(4-fluorophenoxy)propyl]-4-methyl-4-piperidinyl]5-iodo-2-methoxybenzamide ((123)I-R91150) characterization study, ketanserin challenges were performed on healthy volunteers with the aim of assessing the specificity of (123)I-R91150 binding to subtype 2A of the 5-hydroxytryptamine receptor (5-HT(2A)), the sensitivity of (123)I-R91150 SPECT in measuring ligand displacement, the relationship between ketanserin plasma concentrations and (123)I-R91150 displacement, and the suitability of the cerebellum as a reference region for quantification.lld:pubmed
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pubmed-article:16741301pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:16741301pubmed:articleTitleCharacterization of the SPECT 5-HT2A receptor ligand 123I-R91150 in healthy volunteers: part 2--ketanserin displacement.lld:pubmed
pubmed-article:16741301pubmed:affiliationExperimental Medical Sciences, Clinical Pharmacology Discovery Medicine, Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline, Barcelona, Spain.lld:pubmed
pubmed-article:16741301pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16741301pubmed:publicationTypeClinical Triallld:pubmed
pubmed-article:16741301pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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