| pubmed-article:16740728 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16740728 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:16740728 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:16740728 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:16740728 | lifeskim:mentions | umls-concept:C0968296 | lld:lifeskim |
| pubmed-article:16740728 | lifeskim:mentions | umls-concept:C0184511 | lld:lifeskim |
| pubmed-article:16740728 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:16740728 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:16740728 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:16740728 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:16740728 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:16740728 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:16740728 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:16740728 | pubmed:dateCreated | 2006-6-2 | lld:pubmed |
| pubmed-article:16740728 | pubmed:abstractText | Restricted and high-level expression of interleukin-13 receptor alpha2 (IL-13Ralpha2) in a majority of human malignant gliomas makes this protein an attractive vaccine target. We have previously described the identification of the IL-13Ralpha2(345-353) peptide as a human leukocyte antigen-A2 (HLA-A2)-restricted CTL epitope. However, as it remains unclear how efficiently peptide-based vaccines can induce specific CTLs in patients with malignant gliomas, we have examined whether analogue epitopes could elicit heteroclitic antitumor T-cell responses versus wild-type peptides. We have created three IL-13Ralpha2 analogue peptides by substitutions of the COOH-terminal isoleucine (I) for valine (V) and the NH(2)-terminal tryptophan (W) for either alanine (A), glutamic acid (E), or nonsubstituted (W; designated as 1A9V, 1E9V, and 9V, respectively). In comparison with the native IL-13Ralpha2 epitope, the analogue peptides 9V and 1A9V displayed higher levels of binding affinity and stability in HLA-A2 complexes and yielded an improved stimulatory index for patient-derived, specific CTLs against the native epitope expressed by HLA-A2(+) glioma cells. In HLA-A2-transgenic HHD mice, immunization with the peptides 9V and 1A9V induced enhanced levels of CTL reactivity and protective immunity against an intracranial challenge with IL13Ralpha2-expressing syngeneic tumors when compared with vaccines containing the native IL-13Ralpha2 epitope. These findings indicate highly immunogenic IL-13Ralpha2 peptide analogues may be useful for the development of vaccines capable of effectively expanding IL-13Ralpha2-specific, tumor-reactive CTLs in glioma patients. | lld:pubmed |
| pubmed-article:16740728 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16740728 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16740728 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16740728 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16740728 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16740728 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16740728 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16740728 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:16740728 | pubmed:author | pubmed-author:HatanoManabuM | lld:pubmed |
| pubmed-article:16740728 | pubmed:author | pubmed-author:PollackIan... | lld:pubmed |
| pubmed-article:16740728 | pubmed:author | pubmed-author:StorkusWalter... | lld:pubmed |
| pubmed-article:16740728 | pubmed:author | pubmed-author:OkadaHidehoH | lld:pubmed |
| pubmed-article:16740728 | pubmed:author | pubmed-author:SatoHidemitsu... | lld:pubmed |
| pubmed-article:16740728 | pubmed:author | pubmed-author:NishimuraFumi... | lld:pubmed |
| pubmed-article:16740728 | pubmed:author | pubmed-author:DusakJill EJE | lld:pubmed |
| pubmed-article:16740728 | pubmed:author | pubmed-author:EguchiJunichi... | lld:pubmed |
| pubmed-article:16740728 | pubmed:author | pubmed-author:ZhuXinmeiX | lld:pubmed |
| pubmed-article:16740728 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16740728 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16740728 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:16740728 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16740728 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16740728 | pubmed:pagination | 5883-91 | lld:pubmed |
| pubmed-article:16740728 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:16740728 | pubmed:meshHeading | pubmed-meshheading:16740728... | lld:pubmed |
| pubmed-article:16740728 | pubmed:meshHeading | pubmed-meshheading:16740728... | lld:pubmed |
| pubmed-article:16740728 | pubmed:meshHeading | pubmed-meshheading:16740728... | lld:pubmed |
| pubmed-article:16740728 | pubmed:meshHeading | pubmed-meshheading:16740728... | lld:pubmed |
| pubmed-article:16740728 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16740728 | pubmed:articleTitle | Identification of interleukin-13 receptor alpha2 peptide analogues capable of inducing improved antiglioma CTL responses. | lld:pubmed |
| pubmed-article:16740728 | pubmed:affiliation | Department of Neurological Surgery, University of Pittsburgh School of Medicine, USA. | lld:pubmed |
| pubmed-article:16740728 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16740728 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16740728 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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