| pubmed-article:16740288 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16740288 | lifeskim:mentions | umls-concept:C0682458 | lld:lifeskim |
| pubmed-article:16740288 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:16740288 | lifeskim:mentions | umls-concept:C0042210 | lld:lifeskim |
| pubmed-article:16740288 | lifeskim:mentions | umls-concept:C0000932 | lld:lifeskim |
| pubmed-article:16740288 | lifeskim:mentions | umls-concept:C1517365 | lld:lifeskim |
| pubmed-article:16740288 | lifeskim:mentions | umls-concept:C0052712 | lld:lifeskim |
| pubmed-article:16740288 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:16740288 | lifeskim:mentions | umls-concept:C1522673 | lld:lifeskim |
| pubmed-article:16740288 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16740288 | pubmed:dateCreated | 2006-8-21 | lld:pubmed |
| pubmed-article:16740288 | pubmed:abstractText | Here, we use a vaccine consisting of DNA priming followed by MVA boosting in rhesus macaques to investigate the ability of GM-CSF DNA to serve as an adjuvant for the elicitation of neutralizing Ab against an HIV-1 Env. The trial used Gag, Pol, and Env sequences from SHIV-89.6 in the immunogens and a neutralization escape variant of SHIV-89.6, SHIV-89.6P, for challenge. Co-delivery of GM-CSF and vaccine DNAs enhanced the temporal appearance of neutralizing Ab and broadened the specificity of the neutralizing activity to include SHIV-89.6P. Two long-term SHIV-89.6 infections elicited neutralizing activity for SHIV-89.6 but not SHIV-89.6P. Studies on the avidity of the anti-Env antisera revealed that the GM-CSF-adjuvanted vaccine had elicited higher avidity Ab than the non-adjuvanted vaccine or the infection. The GM-CSF-adjuvanted group showed a trend towards better control of the challenge infection and had better control of re-emergent virus (P < 0.01) than the non-adjuvanted group. | lld:pubmed |
| pubmed-article:16740288 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16740288 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16740288 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16740288 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16740288 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16740288 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16740288 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16740288 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16740288 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16740288 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16740288 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16740288 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16740288 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16740288 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16740288 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16740288 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16740288 | pubmed:issn | 0042-6822 | lld:pubmed |
| pubmed-article:16740288 | pubmed:author | pubmed-author:McClureHarold... | lld:pubmed |
| pubmed-article:16740288 | pubmed:author | pubmed-author:MontefioriDav... | lld:pubmed |
| pubmed-article:16740288 | pubmed:author | pubmed-author:MossBernardB | lld:pubmed |
| pubmed-article:16740288 | pubmed:author | pubmed-author:RobinsonJames... | lld:pubmed |
| pubmed-article:16740288 | pubmed:author | pubmed-author:VillingerFran... | lld:pubmed |
| pubmed-article:16740288 | pubmed:author | pubmed-author:SharmaSunitaS | lld:pubmed |
| pubmed-article:16740288 | pubmed:author | pubmed-author:AmaraRama... | lld:pubmed |
| pubmed-article:16740288 | pubmed:author | pubmed-author:WyattLinda... | lld:pubmed |
| pubmed-article:16740288 | pubmed:author | pubmed-author:EarlPatricia... | lld:pubmed |
| pubmed-article:16740288 | pubmed:author | pubmed-author:RobinsonHarri... | lld:pubmed |
| pubmed-article:16740288 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16740288 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16740288 | pubmed:volume | 352 | lld:pubmed |
| pubmed-article:16740288 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16740288 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16740288 | pubmed:pagination | 285-94 | lld:pubmed |
| pubmed-article:16740288 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:16740288 | pubmed:meshHeading | pubmed-meshheading:16740288... | lld:pubmed |
| pubmed-article:16740288 | pubmed:meshHeading | pubmed-meshheading:16740288... | lld:pubmed |
| pubmed-article:16740288 | pubmed:meshHeading | pubmed-meshheading:16740288... | lld:pubmed |
| pubmed-article:16740288 | pubmed:meshHeading | pubmed-meshheading:16740288... | lld:pubmed |
| pubmed-article:16740288 | pubmed:meshHeading | pubmed-meshheading:16740288... | lld:pubmed |
| pubmed-article:16740288 | pubmed:meshHeading | pubmed-meshheading:16740288... | lld:pubmed |
| pubmed-article:16740288 | pubmed:meshHeading | pubmed-meshheading:16740288... | lld:pubmed |
| pubmed-article:16740288 | pubmed:meshHeading | pubmed-meshheading:16740288... | lld:pubmed |
| pubmed-article:16740288 | pubmed:meshHeading | pubmed-meshheading:16740288... | lld:pubmed |
| pubmed-article:16740288 | pubmed:meshHeading | pubmed-meshheading:16740288... | lld:pubmed |
| pubmed-article:16740288 | pubmed:meshHeading | pubmed-meshheading:16740288... | lld:pubmed |
| pubmed-article:16740288 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16740288 | pubmed:articleTitle | Studies on GM-CSF DNA as an adjuvant for neutralizing Ab elicited by a DNA/MVA immunodeficiency virus vaccine. | lld:pubmed |
| pubmed-article:16740288 | pubmed:affiliation | Emory Vaccine Center of Emory University School of Medicine, Atlanta, GA 30322, USA. hrobins@rmy.emory.edu | lld:pubmed |
| pubmed-article:16740288 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16740288 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16740288 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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