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pubmed-article:16735799pubmed:abstractTextElevated plasma levels of plasminogen activator inhibitor-1 (PAI-1) are observed in patients with obesity, hypertension and diabetes, and several observations suggest that PAI-1 mediates diabetic vascular complications. Although increased intrarenal expression of PAI-1 is also a feature of diabetic nephropathy, evidence that PAI-1 plays a primary pathogenetic role in the renal pathology is lacking.lld:pubmed
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pubmed-article:16735799pubmed:copyrightInfoCopyright 2006 S. Karger AG, Basel.lld:pubmed
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pubmed-article:16735799pubmed:articleTitlePlasminogen activator inhibitor-1 deficiency has renal benefits but some adverse systemic consequences in diabetic mice.lld:pubmed
pubmed-article:16735799pubmed:affiliationChildren's Hospital and Regional Medical Center, Department of Pediatrics, University of Washington, Seattle, Wash, USA.lld:pubmed
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