| pubmed-article:16734614 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16734614 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:16734614 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:16734614 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:16734614 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:16734614 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:16734614 | lifeskim:mentions | umls-concept:C1332709 | lld:lifeskim |
| pubmed-article:16734614 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:16734614 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:16734614 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:16734614 | lifeskim:mentions | umls-concept:C0205257 | lld:lifeskim |
| pubmed-article:16734614 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:16734614 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16734614 | pubmed:dateCreated | 2006-5-31 | lld:pubmed |
| pubmed-article:16734614 | pubmed:abstractText | Expression of tumour antigen-specific chimaeric receptors in T lymphocytes can redirect their effector functions towards tumour cells. Integration of the signalling domains of the co-stimulatory molecule CD28 into chRec enhances antigen-specific proliferation of polyclonal human T cell populations. While CD28 plays an essential role in the priming of naive CD4(+) T cells, its contribution to effector memory T cell responses is controversial. We compared the function of the chRec with and without the CD28 co-stimulatory domain, expressing it in peripheral blood T cells or Epstein-Barr virus (EBV)-specific T cell lines. The chimaeric T cell receptors contain an extracellular single-chain antibody domain, to give specificity against the tumour ganglioside antigen G(D2). The transduced cytotoxic T lymphocytes (CTL) maintained their specificity for autologous EBV targets and their capacity to proliferate after stimulation with EBV-infected B cells. Intracellular cytokine staining demonstrated efficient and comparable antigen-specific interferon (IFN)-gamma secretion by CTL following engagement of both the native and the chimaeric receptor, independent of chimaeric CD28 signalling. Furthermore, tumour targets were lysed in an antigen-specific manner by both chRec. However, while antigen engagement by CD28 zeta chRec efficiently induced expansion of polyclonal peripheral blood lymphocytes in an antigen-dependent manner, CD28 signalling did not induce proliferation of EBV-CTL in response to antigen-expressing tumour cells. Thus, the co-stimulatory requirement for the efficient activation response of antigen-specific memory cells cannot be mimicked simply by combining CD28 and zeta signalling. The full potential of this highly cytolytic T cell population for adoptive immunotherapy of cancer requires further exploration of their co-stimulatory requirements. | lld:pubmed |
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| pubmed-article:16734614 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16734614 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16734614 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16734614 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16734614 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16734614 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16734614 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:16734614 | pubmed:author | pubmed-author:VormoorJJ | lld:pubmed |
| pubmed-article:16734614 | pubmed:author | pubmed-author:JuergensHH | lld:pubmed |
| pubmed-article:16734614 | pubmed:author | pubmed-author:RossigCC | lld:pubmed |
| pubmed-article:16734614 | pubmed:author | pubmed-author:PschererSS | lld:pubmed |
| pubmed-article:16734614 | pubmed:author | pubmed-author:LandmeierSS | lld:pubmed |
| pubmed-article:16734614 | pubmed:author | pubmed-author:AltvaterBB | lld:pubmed |
| pubmed-article:16734614 | pubmed:author | pubmed-author:NiggemeierVV | lld:pubmed |
| pubmed-article:16734614 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16734614 | pubmed:volume | 144 | lld:pubmed |
| pubmed-article:16734614 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16734614 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16734614 | pubmed:pagination | 447-57 | lld:pubmed |
| pubmed-article:16734614 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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