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pubmed-article:16729884pubmed:abstractTextImmortalization is a key step in malignant transformation, but immortalization alone is insufficient for transformation. Human mammary epithelial cell (HMEC) transformation is a complex process that requires additional genetic changes beyond immortalization and can be accomplished in vitro by accumulation of genetic changes and expression of H-ras.lld:pubmed
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pubmed-article:16729884pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:16729884pubmed:articleTitleCytogenetic characterization and H-ras associated transformation of immortalized human mammary epithelial cells.lld:pubmed
pubmed-article:16729884pubmed:affiliationSouthern Illinois University School of Medicine Cancer Institute, P,O, Box 19678, Springfield, IL 62794-9678, USA.lld:pubmed
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