| pubmed-article:16722973 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16722973 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:16722973 | lifeskim:mentions | umls-concept:C2926606 | lld:lifeskim |
| pubmed-article:16722973 | lifeskim:mentions | umls-concept:C0014556 | lld:lifeskim |
| pubmed-article:16722973 | lifeskim:mentions | umls-concept:C2607943 | lld:lifeskim |
| pubmed-article:16722973 | lifeskim:mentions | umls-concept:C0024485 | lld:lifeskim |
| pubmed-article:16722973 | lifeskim:mentions | umls-concept:C1521733 | lld:lifeskim |
| pubmed-article:16722973 | lifeskim:mentions | umls-concept:C1719039 | lld:lifeskim |
| pubmed-article:16722973 | lifeskim:mentions | umls-concept:C0037812 | lld:lifeskim |
| pubmed-article:16722973 | lifeskim:mentions | umls-concept:C0392760 | lld:lifeskim |
| pubmed-article:16722973 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:16722973 | pubmed:dateCreated | 2006-5-25 | lld:pubmed |
| pubmed-article:16722973 | pubmed:abstractText | Up to 30% of patients with temporal lobe epilepsy (TLE) remain without remarkable changes in MRI. In this study we investigated the role of (1)H-MR spectroscopy ((1)H-MRS) in lateralizing the affected hemisphere in the mentioned patient group. Twenty-two consecutive patients diagnosed with TLE were investigated by high resolution MRI and (1)H-MRS. We examined the incidence and diagnostic accuracy of temporal metabolite alterations determined by Linear Combination of Model Spectra (L C Model) via water reference. Metabolite values of each hemisphere of TLE patients were compared with healthy controls. Results of metabolite alterations were related to intensive video EEG focus localization. Reduction of N-acetylaspartate + N-acetylaspartyl-glutamate (tNAA) in the affected hemisphere revealed identification in six of nine patients (66%) with unilateral TLE. Group comparison revealed a significant reduction of tNAA (6.1+/-0.8*) in the involved temporal lobe compared with controls (6.67+/-0.4*, P=0.026). Choline levels were significantly increased in the affected hemisphere (1.42+/-0.17*) compared with healthy controls (1.22+/-0.17*, P=0.035). The results of our study show that (1)H-MRS is able to identify the affected hemisphere of MRI negative TLE patients and can be used as an additive tool in multimodal focus localization. | lld:pubmed |
| pubmed-article:16722973 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16722973 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16722973 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16722973 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16722973 | pubmed:month | May | lld:pubmed |
| pubmed-article:16722973 | pubmed:issn | 1351-5101 | lld:pubmed |
| pubmed-article:16722973 | pubmed:author | pubmed-author:SchwarzMM | lld:pubmed |
| pubmed-article:16722973 | pubmed:author | pubmed-author:StefanHH | lld:pubmed |
| pubmed-article:16722973 | pubmed:author | pubmed-author:HammenTT | lld:pubmed |
| pubmed-article:16722973 | pubmed:author | pubmed-author:KerlingFF | lld:pubmed |
| pubmed-article:16722973 | pubmed:author | pubmed-author:TomandlBB | lld:pubmed |
| pubmed-article:16722973 | pubmed:author | pubmed-author:KeckBB | lld:pubmed |
| pubmed-article:16722973 | pubmed:author | pubmed-author:GanslandtOO | lld:pubmed |
| pubmed-article:16722973 | pubmed:author | pubmed-author:DörflerAA | lld:pubmed |
| pubmed-article:16722973 | pubmed:author | pubmed-author:StadlbauerAA | lld:pubmed |
| pubmed-article:16722973 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16722973 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:16722973 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16722973 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16722973 | pubmed:pagination | 482-90 | lld:pubmed |
| pubmed-article:16722973 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16722973 | pubmed:meshHeading | pubmed-meshheading:16722973... | lld:pubmed |
| pubmed-article:16722973 | pubmed:meshHeading | pubmed-meshheading:16722973... | lld:pubmed |
| pubmed-article:16722973 | pubmed:meshHeading | pubmed-meshheading:16722973... | lld:pubmed |
| pubmed-article:16722973 | pubmed:meshHeading | pubmed-meshheading:16722973... | lld:pubmed |
| pubmed-article:16722973 | pubmed:meshHeading | pubmed-meshheading:16722973... | lld:pubmed |
| pubmed-article:16722973 | pubmed:meshHeading | pubmed-meshheading:16722973... | lld:pubmed |
| pubmed-article:16722973 | pubmed:meshHeading | pubmed-meshheading:16722973... | lld:pubmed |
| pubmed-article:16722973 | pubmed:meshHeading | pubmed-meshheading:16722973... | lld:pubmed |
| pubmed-article:16722973 | pubmed:meshHeading | pubmed-meshheading:16722973... | lld:pubmed |
| pubmed-article:16722973 | pubmed:meshHeading | pubmed-meshheading:16722973... | lld:pubmed |
| pubmed-article:16722973 | pubmed:meshHeading | pubmed-meshheading:16722973... | lld:pubmed |
| pubmed-article:16722973 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16722973 | pubmed:articleTitle | Identifying the affected hemisphere by (1)H-MR spectroscopy in patients with temporal lobe epilepsy and no pathological findings in high resolution MRI. | lld:pubmed |
| pubmed-article:16722973 | pubmed:affiliation | Clinics of Neurology, Epilepsy Center (ZEE), University of Erlangen-Nuremberg, Erlangen, Germany. Thilo.Hammen@neurozentrum.imed.uni-erlangen.de | lld:pubmed |
| pubmed-article:16722973 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16722973 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
