| pubmed-article:16722640 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16722640 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:16722640 | lifeskim:mentions | umls-concept:C0521390 | lld:lifeskim |
| pubmed-article:16722640 | lifeskim:mentions | umls-concept:C0034807 | lld:lifeskim |
| pubmed-article:16722640 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:16722640 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:16722640 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:16722640 | lifeskim:mentions | umls-concept:C0815278 | lld:lifeskim |
| pubmed-article:16722640 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:16722640 | pubmed:dateCreated | 2006-5-25 | lld:pubmed |
| pubmed-article:16722640 | pubmed:abstractText | A GABA(A) receptor study of several B-nor analogues of allopregnanolone and pregnanolone has been carried out. B-norallopregnanolone (i.e., 3alpha-hydroxy-7-nor-5alpha-pregnan-20-one) was found comparable to allopregnanolone when measured with labeled TBPS. Analogous results were obtained from their effect on neurons in culture: this time, both 3alpha-hydroxy-7-nor-5xi-pregnan-20-ones (5 and 6) were found to stimulate [3H]flunitrazepam binding and GABA-induced 36Cl- influx. These effects were inhibited by GABA(A) receptor antagonists. Other analogues carrying electronegative substituents (epoxides 9 and 10 and ketone 12) in the B ring were inactive. Similarly, B-normal ketones 17, and 18 and 6-azasteroids 20 and 21 were also inactive. B-Nor analogues 5 and 6 did not induce neurotoxicity at relevant concentrations. A computational analysis of active and inactive neurosteroid analogues allowed the proposal of a 3D pharmacophoric hypothesis of their interaction with the GABA(A) receptor. | lld:pubmed |
| pubmed-article:16722640 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16722640 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16722640 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16722640 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16722640 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16722640 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16722640 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16722640 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16722640 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16722640 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16722640 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:16722640 | pubmed:author | pubmed-author:KasalAlexande... | lld:pubmed |
| pubmed-article:16722640 | pubmed:author | pubmed-author:GarcíaDaniel... | lld:pubmed |
| pubmed-article:16722640 | pubmed:author | pubmed-author:SuñolCristina... | lld:pubmed |
| pubmed-article:16722640 | pubmed:author | pubmed-author:BujonsJordiJ | lld:pubmed |
| pubmed-article:16722640 | pubmed:author | pubmed-author:BabotZoilaZ | lld:pubmed |
| pubmed-article:16722640 | pubmed:author | pubmed-author:KristofíkováZ... | lld:pubmed |
| pubmed-article:16722640 | pubmed:author | pubmed-author:MatyásLiborL | lld:pubmed |
| pubmed-article:16722640 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16722640 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16722640 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:16722640 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16722640 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16722640 | pubmed:pagination | 3225-34 | lld:pubmed |
| pubmed-article:16722640 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16722640 | pubmed:meshHeading | pubmed-meshheading:16722640... | lld:pubmed |
| pubmed-article:16722640 | pubmed:meshHeading | pubmed-meshheading:16722640... | lld:pubmed |
| pubmed-article:16722640 | pubmed:meshHeading | pubmed-meshheading:16722640... | lld:pubmed |
| pubmed-article:16722640 | pubmed:meshHeading | pubmed-meshheading:16722640... | lld:pubmed |
| pubmed-article:16722640 | pubmed:meshHeading | pubmed-meshheading:16722640... | lld:pubmed |
| pubmed-article:16722640 | pubmed:meshHeading | pubmed-meshheading:16722640... | lld:pubmed |
| pubmed-article:16722640 | pubmed:meshHeading | pubmed-meshheading:16722640... | lld:pubmed |
| pubmed-article:16722640 | pubmed:meshHeading | pubmed-meshheading:16722640... | lld:pubmed |
| pubmed-article:16722640 | pubmed:meshHeading | pubmed-meshheading:16722640... | lld:pubmed |
| pubmed-article:16722640 | pubmed:meshHeading | pubmed-meshheading:16722640... | lld:pubmed |
| pubmed-article:16722640 | pubmed:meshHeading | pubmed-meshheading:16722640... | lld:pubmed |
| pubmed-article:16722640 | pubmed:meshHeading | pubmed-meshheading:16722640... | lld:pubmed |
| pubmed-article:16722640 | pubmed:meshHeading | pubmed-meshheading:16722640... | lld:pubmed |
| pubmed-article:16722640 | pubmed:meshHeading | pubmed-meshheading:16722640... | lld:pubmed |
| pubmed-article:16722640 | pubmed:meshHeading | pubmed-meshheading:16722640... | lld:pubmed |
| pubmed-article:16722640 | pubmed:meshHeading | pubmed-meshheading:16722640... | lld:pubmed |
| pubmed-article:16722640 | pubmed:meshHeading | pubmed-meshheading:16722640... | lld:pubmed |
| pubmed-article:16722640 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16722640 | pubmed:articleTitle | Activity of B-nor analogues of neurosteroids on the GABA(A) receptor in primary neuronal cultures. | lld:pubmed |
| pubmed-article:16722640 | pubmed:affiliation | Institut d'Investigacions Biomèdiques de Barcelona, Consejo Superior de Investigaciones Científicas, CSIC-IDIBAPS, Barcelona, Spain. | lld:pubmed |
| pubmed-article:16722640 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16722640 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:16722640 | lld:chembl |
