| pubmed-article:16721586 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16721586 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
| pubmed-article:16721586 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:16721586 | lifeskim:mentions | umls-concept:C0022661 | lld:lifeskim |
| pubmed-article:16721586 | lifeskim:mentions | umls-concept:C0403447 | lld:lifeskim |
| pubmed-article:16721586 | lifeskim:mentions | umls-concept:C0071744 | lld:lifeskim |
| pubmed-article:16721586 | lifeskim:mentions | umls-concept:C1273070 | lld:lifeskim |
| pubmed-article:16721586 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:16721586 | pubmed:dateCreated | 2006-8-9 | lld:pubmed |
| pubmed-article:16721586 | pubmed:abstractText | Previous studies indicate that serum cystatin C predicts incident heart failure in older adults. Children with chronic kidney disease (CKD) develop left ventricular (LV) diastolic dysfunction, often the initial abnormality of cardiac function. We hypothesized that cystatin C might predict LV diastolic dysfunction in children with CKD. Fifty-seven subjects, aged 6-21 years, with stage 2-4 CKD underwent echocardiography. Diastole was assessed from transmitral Doppler [maximum early (E wave) and late (A wave) diastolic flow velocities (E/A ratio)] and from tissue Doppler [septal mitral annular peak velocities (E')]. LV filling pressures were determined, using a ratio of E/E'. Fourteen (25%) patients had low E' and 15 (26%) had high E/E'. Children with abnormal E' or E/E' had significantly higher cystatin C levels than children with normal indices (P<0.05). Neither serum creatinine nor measured glomerular filtration rate (GFR) significantly correlated with E' or E/E'. Stepwise multiple regression analysis showed that cystatin C (beta=-0.825, P=0.023) and left ventricular mass (LVM) index (beta=0.099, P=0.006) independently predicted E'; LVM index independently predicted E/E' (beta=0.0173, P=0.01). We conclude that, in contrast to measured GFR or serum creatinine level, elevated serum cystatin C might be associated with diastolic dysfunction in children with CKD. | lld:pubmed |
| pubmed-article:16721586 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16721586 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16721586 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16721586 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16721586 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16721586 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16721586 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16721586 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16721586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16721586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16721586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16721586 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16721586 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16721586 | pubmed:issn | 0931-041X | lld:pubmed |
| pubmed-article:16721586 | pubmed:author | pubmed-author:DevarajanPras... | lld:pubmed |
| pubmed-article:16721586 | pubmed:author | pubmed-author:MishraJayaJ | lld:pubmed |
| pubmed-article:16721586 | pubmed:author | pubmed-author:MitsnefesMark... | lld:pubmed |
| pubmed-article:16721586 | pubmed:author | pubmed-author:KartalJanisJ | lld:pubmed |
| pubmed-article:16721586 | pubmed:author | pubmed-author:KimbalThomasT | lld:pubmed |
| pubmed-article:16721586 | pubmed:author | pubmed-author:KathmanThelma... | lld:pubmed |
| pubmed-article:16721586 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16721586 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:16721586 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16721586 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16721586 | pubmed:pagination | 1293-8 | lld:pubmed |
| pubmed-article:16721586 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:16721586 | pubmed:meshHeading | pubmed-meshheading:16721586... | lld:pubmed |
| pubmed-article:16721586 | pubmed:meshHeading | pubmed-meshheading:16721586... | lld:pubmed |
| pubmed-article:16721586 | pubmed:meshHeading | pubmed-meshheading:16721586... | lld:pubmed |
| pubmed-article:16721586 | pubmed:meshHeading | pubmed-meshheading:16721586... | lld:pubmed |
| pubmed-article:16721586 | pubmed:meshHeading | pubmed-meshheading:16721586... | lld:pubmed |
| pubmed-article:16721586 | pubmed:meshHeading | pubmed-meshheading:16721586... | lld:pubmed |
| pubmed-article:16721586 | pubmed:meshHeading | pubmed-meshheading:16721586... | lld:pubmed |
| pubmed-article:16721586 | pubmed:meshHeading | pubmed-meshheading:16721586... | lld:pubmed |
| pubmed-article:16721586 | pubmed:meshHeading | pubmed-meshheading:16721586... | lld:pubmed |
| pubmed-article:16721586 | pubmed:meshHeading | pubmed-meshheading:16721586... | lld:pubmed |
| pubmed-article:16721586 | pubmed:meshHeading | pubmed-meshheading:16721586... | lld:pubmed |
| pubmed-article:16721586 | pubmed:meshHeading | pubmed-meshheading:16721586... | lld:pubmed |
| pubmed-article:16721586 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16721586 | pubmed:articleTitle | Serum cystatin C and left ventricular diastolic dysfunction in children with chronic kidney disease. | lld:pubmed |
| pubmed-article:16721586 | pubmed:affiliation | Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, University of Cincinnati, MLC 7022, 3333 Burnet Avenue, Cincinnati, OH, 45229-3039, USA. mark.mitsnefes@cchmc.org | lld:pubmed |
| pubmed-article:16721586 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16721586 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16721586 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16721586 | lld:pubmed |
