| pubmed-article:16721373 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16721373 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:16721373 | lifeskim:mentions | umls-concept:C1512505 | lld:lifeskim |
| pubmed-article:16721373 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:16721373 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:16721373 | lifeskim:mentions | umls-concept:C1419053 | lld:lifeskim |
| pubmed-article:16721373 | lifeskim:mentions | umls-concept:C1426588 | lld:lifeskim |
| pubmed-article:16721373 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:16721373 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
| pubmed-article:16721373 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:16721373 | lifeskim:mentions | umls-concept:C0078460 | lld:lifeskim |
| pubmed-article:16721373 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:16721373 | pubmed:dateCreated | 2006-5-31 | lld:pubmed |
| pubmed-article:16721373 | pubmed:abstractText | WEB-2086 -- an antagonist of platelet-activating factor receptor (PAFR) with known anti-inflammatory, antiangiogenic and antileukaemic properties -- also proved to inhibit the proliferation in human solid tumour cell lines of different histology, and with much higher efficacy than in normal fibroblasts. A detailed analysis of WEB-2086 anticancer activity was then performed focusing on breast adenocarcinoma MCF-7 and MDA-MB-231 cells. WEB-2086-treated cells, either expressing (MCF-7) or unexpressing (MDA-MB-231) the oestrogen receptor (ER)alpha, underwent a dose-dependent growth arrest (IC(50)=0.65+/-0.09 and 0.41+/-0.07 mM, respectively) and accumulation in G(0)-G(1) phase. WEB-2086 also induced morphological and functional changes typical of mature mammary phenotype including (i) cell enlargement and massive neutral lipid deposition (best accomplished in MCF-7 cells); (ii) decrease in motility and active cathepsin D levels (mainly observed in highly invasive MDA-MB-231 cells). The expression of ERalpha was neither increased nor reactivated in treated MCF-7 or MDA-MB-231 cells, respectively. WEB-2086-induced differentiation in breast cancer cells involved the upregulation of PTEN, a key tumour suppressor protein opposing tumorigenesis, and was apparently independent of p53, PAFR, peripheral benzodiazepine receptor and ERalpha status. Overall, WEB-2086 can be proposed as an effective antiproliferative and differentiative agent with interesting translational opportunities to treat breast cancers in support to conventional chemotherapy. | lld:pubmed |
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| pubmed-article:16721373 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16721373 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16721373 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16721373 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16721373 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16721373 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:16721373 | pubmed:author | pubmed-author:PaolettiFF | lld:pubmed |
| pubmed-article:16721373 | pubmed:author | pubmed-author:Di LolloSS | lld:pubmed |
| pubmed-article:16721373 | pubmed:author | pubmed-author:CaporaleRR | lld:pubmed |
| pubmed-article:16721373 | pubmed:author | pubmed-author:VannucchiA... | lld:pubmed |
| pubmed-article:16721373 | pubmed:author | pubmed-author:PaglieraniMM | lld:pubmed |
| pubmed-article:16721373 | pubmed:author | pubmed-author:CellaiCC | lld:pubmed |
| pubmed-article:16721373 | pubmed:author | pubmed-author:PancrazziAA | lld:pubmed |
| pubmed-article:16721373 | pubmed:author | pubmed-author:LaurenzanaAA | lld:pubmed |
| pubmed-article:16721373 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16721373 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:16721373 | pubmed:volume | 94 | lld:pubmed |
| pubmed-article:16721373 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16721373 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16721373 | pubmed:pagination | 1637-42 | lld:pubmed |
| pubmed-article:16721373 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:16721373 | pubmed:meshHeading | pubmed-meshheading:16721373... | lld:pubmed |
| pubmed-article:16721373 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16721373 | pubmed:articleTitle | Growth inhibition and differentiation of human breast cancer cells by the PAFR antagonist WEB-2086. | lld:pubmed |
| pubmed-article:16721373 | pubmed:affiliation | Department of Experimental Pathology and Oncology, School of Medicine, University of Florence, Viale G. B. Morgagni 50, 50134 Florence, Italy. | lld:pubmed |
| pubmed-article:16721373 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16721373 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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