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pubmed-article:1671890pubmed:abstractTextThe part that candida plays in antibiotic-associated diarrhoea was investigated in 24 elderly inpatients (mean age 74 years) who tested negative for Clostridium difficile toxin and other intestinal pathogens. 7 had intestinal overgrowth of Candida species (greater than or equal to 10(5) cfu/ml). None of the 24 matched, antibiotic-treated controls without diarrhoea had candida overgrowth. All 5 patients with diarrhoea and candida overgrowth treated with oral nystatin responded with resolution of diarrhoea and lowering of faecal counts to less than 10(4) cfu/ml within 7 days of start of antifungal therapy despite continuation of antibacterial therapy. In the other 2 patients with candida overgrowth, the diarrhoea subsided spontaneously and faecal candida counts returned to normal (less than 10(4) cfu/ml) after antibacterial agents were withdrawn. In patients without candida overgrowth, diarrhoea persisted until antibiotics were withdrawn, at a mean of 16 days after study entry.lld:pubmed
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pubmed-article:1671890pubmed:articleTitleRole of candida in pathogenesis of antibiotic-associated diarrhoea in elderly inpatients.lld:pubmed
pubmed-article:1671890pubmed:affiliationInfectious Disease Section, Booth Memorial Medical Centre, Flushing, New York 11355.lld:pubmed
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